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- W1041934052 abstract "Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes infections in patients with compromised immunity. Several previous studies are animal based, but we have established a human neutrophil/macrophage PA infection model to investigate phagocyte collaboration in PA control. Objective i. to investigate the ability of human macrophage-neutrophil co-cultures to control Pseudomonas growth, promote inflammation and cause tissue damage, and ii. to determine how the presence of pro-inflammatory cytokines such as IFN-γ and IL-17A affect the outcome of the infection of macrophage-neutrophils co-cultures with PA. Methods A robust procedure has been established where, neutrophils or macrophages or both are infected with PA with or without cytokines under opsonic and or non-opsonic conditions, and the samples analysed for bacterial colony forming units (CFU) or Flow cytometry. Results The findings so far indicate: 1.macrophages have a minor effect on the control of PA but coordinate the immune response to PA infection; 2.phagocytosis of PA by neutrophils under non-opsonic conditions depends on cell density; 3.as expected, serum enhances neutrophil-mediated killing of PA; 4.IL-17A enhances neutrophil-mediated killing of PA under opsonic conditions and 5.neutrophils synergise with macrophages in clearing PA infection. Conclusion 1.Macrophages coordinate the immune response to PA by producing a number of cytokines. 2.Neutrophil control of PA infection is enhanced by human complement. 3.The cytokine IL-17A enhances the ability of human neutrophils to control PA infection. 4.Neutrophils and macrophages collaborate in clearing PA infections." @default.
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- W1041934052 date "2015-06-01" @default.
- W1041934052 modified "2023-10-15" @default.
- W1041934052 title "34 Phagocyte collaboration for the control of Pseudomonas aeruginosa" @default.
- W1041934052 doi "https://doi.org/10.1016/s1569-1993(15)30211-3" @default.
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