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- W104199383 abstract "The discovery of atrial natriuretic peptide (ANP) in the heart some 15 yr ago (1) prompted an explosion of research directed toward understanding both the integrated physiological roles and the potential sites of action of this vasoactive peptide. These studies pointed to the central nervous system (CNS), and in particular to regions of the brain with recognized regulatory roles in the control of body fluid balance, as locations at which ANP may play significant roles in normal physiological control mechanisms. The early description of binding sites for ANP within localized regions of the brain (2), combined with reports of ANP-like immunoreactivity within some of these areas (3), argued that, in addition to its hormonal actions in the periphery, ANP may act as a nonconventional neurotransmitter within the CNS (4,5). Many studies have since attempted to define functional roles for ANP within the brain using intracerebroventricular (icv) and direct tissue administration techniques. In addition, a small number of electrophysiological studies have attempted to define the precise actions of ANP on specific groups of neurons in the brain. Such studies have been complicated by the subsequent identification first of brain natriuretic peptide (BNP), which has since been demonstrated to be produced in the periphery rather than the brain, and finally CNP (the “C” prefix represents alphabetical order of discovery), which has now been confirmed to be the primary form of the peptide found within the brain (6).KeywordsNatriuretic PeptideBrain Natriuretic PeptideAtrial Natriuretic PeptideAtrial Natriuretic FactorArea PostremaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W104199383 created "2016-06-24" @default.
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- W104199383 date "1997-01-01" @default.
- W104199383 modified "2023-09-22" @default.
- W104199383 title "Natriuretic Peptide Actions in the Brain" @default.
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- W104199383 doi "https://doi.org/10.1007/978-1-4612-3960-4_12" @default.
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