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- W1042017292 abstract "Objective To investigate the mitogen-activated protein kinase(MAPK)signal transduction pathway induced by fibronectin(FN) in human fetal lung fibroblast cells (HFL1). Methods The HFL1 was stimulated with different concentrations of FN. The effects of extracellular-signal regulated protein kinase(ERK)inhibitor PD98059 and p38MAPK inhibitor SB203580 on cell growth induced by FN were observed. The growth rate of cells was detected by MTT assay. Results FN enhanced the HFL1 proliferation in a dose-dependent manner. The effect of FN on the proliferation of HFL1 was significant at the concentration of 50 ng/ml. Proliferation of HFL1 induced by FN was suppressed by ERK inhibitor PD98059 and p38MAPK inhibitor SB203580. Conclusion The proliferation of HFL1 induced by FN may through the MAPK signal transduction pathway." @default.
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- W1042017292 date "2009-01-01" @default.
- W1042017292 modified "2023-09-28" @default.
- W1042017292 title "Studies on MAPK signal transduction pathway induced by fibronectin in human fetal lung fibroblast cells." @default.
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