Matches in SemOpenAlex for { <https://semopenalex.org/work/W1042087181> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1042087181 endingPage "60" @default.
- W1042087181 startingPage "755" @default.
- W1042087181 abstract "Various drugs added to the culture medium of rabbit mammary gland were assayed for their capacity to affect the lactogenic and the mammogenic activities of prolactin. Three lysosomotropic agents NH4Cl, chloroquine and methylamine which were previously demonstrated to inhibit the degradation of the hormone-receptor complex after its internalization (down-regulation) did not prevent the initiation of casein synthesis, of lactose synthetase activity and of DNA synthesis. Five microtubule disrupting drugs, colchicine, colcemid, vinblastin, podophyllotoxin and nocodazole inhibited the induction of casein and DNA synthesis by prolactin whereas two inactive analogues, trimethylcolchicinic acid and lumicolchicine had no effect. None of these drugs exhibited any general cytotoxic effect as judged by the capacity of the tissue to incorporate 14C aminoacids into total proteins and 3H-uridine into total RNA. The microtubule disrupting drugs did not greatly reduce the rate of casein synthesis in the cultured mammary tissue explanted from lactating rabbits. The data suggest that the down-regulation of prolactin receptor is not strictly required for the two considered prolactin activities. By contrast, the integrity of microtubules, or at least of structures in which tubulin is involved, is necessary to ensure a normal transmission of the prolactin information responsible for the initiation of milk and DNA synthesis. In addition, the fact that the lactogenic and the mammogenic activities of prolactin are affected by the same drugs suggests that these two properties of the hormone are mediated by cellular mechanisms which have at least one common step." @default.
- W1042087181 created "2016-06-24" @default.
- W1042087181 creator A5028272840 @default.
- W1042087181 date "1980-10-01" @default.
- W1042087181 modified "2023-09-23" @default.
- W1042087181 title "Effect of various lysosomotropic agents and microtubule disrupting drugs on the lactogenic and the mammogenic action of prolactin." @default.
- W1042087181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6161010" @default.
- W1042087181 hasPublicationYear "1980" @default.
- W1042087181 type Work @default.
- W1042087181 sameAs 1042087181 @default.
- W1042087181 citedByCount "7" @default.
- W1042087181 crossrefType "journal-article" @default.
- W1042087181 hasAuthorship W1042087181A5028272840 @default.
- W1042087181 hasConcept C142669718 @default.
- W1042087181 hasConcept C1491633281 @default.
- W1042087181 hasConcept C185592680 @default.
- W1042087181 hasConcept C202751555 @default.
- W1042087181 hasConcept C20418707 @default.
- W1042087181 hasConcept C2776095844 @default.
- W1042087181 hasConcept C2776120743 @default.
- W1042087181 hasConcept C2776636253 @default.
- W1042087181 hasConcept C2776694085 @default.
- W1042087181 hasConcept C2777292972 @default.
- W1042087181 hasConcept C2779064019 @default.
- W1042087181 hasConcept C2779363559 @default.
- W1042087181 hasConcept C2781031661 @default.
- W1042087181 hasConcept C54355233 @default.
- W1042087181 hasConcept C552990157 @default.
- W1042087181 hasConcept C55493867 @default.
- W1042087181 hasConcept C64241487 @default.
- W1042087181 hasConcept C71315377 @default.
- W1042087181 hasConcept C86803240 @default.
- W1042087181 hasConcept C95444343 @default.
- W1042087181 hasConcept C98274493 @default.
- W1042087181 hasConceptScore W1042087181C142669718 @default.
- W1042087181 hasConceptScore W1042087181C1491633281 @default.
- W1042087181 hasConceptScore W1042087181C185592680 @default.
- W1042087181 hasConceptScore W1042087181C202751555 @default.
- W1042087181 hasConceptScore W1042087181C20418707 @default.
- W1042087181 hasConceptScore W1042087181C2776095844 @default.
- W1042087181 hasConceptScore W1042087181C2776120743 @default.
- W1042087181 hasConceptScore W1042087181C2776636253 @default.
- W1042087181 hasConceptScore W1042087181C2776694085 @default.
- W1042087181 hasConceptScore W1042087181C2777292972 @default.
- W1042087181 hasConceptScore W1042087181C2779064019 @default.
- W1042087181 hasConceptScore W1042087181C2779363559 @default.
- W1042087181 hasConceptScore W1042087181C2781031661 @default.
- W1042087181 hasConceptScore W1042087181C54355233 @default.
- W1042087181 hasConceptScore W1042087181C552990157 @default.
- W1042087181 hasConceptScore W1042087181C55493867 @default.
- W1042087181 hasConceptScore W1042087181C64241487 @default.
- W1042087181 hasConceptScore W1042087181C71315377 @default.
- W1042087181 hasConceptScore W1042087181C86803240 @default.
- W1042087181 hasConceptScore W1042087181C95444343 @default.
- W1042087181 hasConceptScore W1042087181C98274493 @default.
- W1042087181 hasIssue "2" @default.
- W1042087181 hasLocation W10420871811 @default.
- W1042087181 hasOpenAccess W1042087181 @default.
- W1042087181 hasPrimaryLocation W10420871811 @default.
- W1042087181 hasRelatedWork W1042087181 @default.
- W1042087181 hasRelatedWork W1979766205 @default.
- W1042087181 hasRelatedWork W1984286290 @default.
- W1042087181 hasRelatedWork W2028069892 @default.
- W1042087181 hasRelatedWork W2088442532 @default.
- W1042087181 hasRelatedWork W2089802829 @default.
- W1042087181 hasRelatedWork W2093789912 @default.
- W1042087181 hasRelatedWork W2096873963 @default.
- W1042087181 hasRelatedWork W2415706340 @default.
- W1042087181 hasRelatedWork W2470860888 @default.
- W1042087181 hasVolume "22" @default.
- W1042087181 isParatext "false" @default.
- W1042087181 isRetracted "false" @default.
- W1042087181 magId "1042087181" @default.
- W1042087181 workType "article" @default.