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- W104267072 endingPage "259" @default.
- W104267072 startingPage "229" @default.
- W104267072 abstract "The release of neurotransmitter molecules from synaptic vesicles is of outmost importance for the communication between cells in the nervous system. Before their fusion with the plasma membrane, vesicles undergo a multistep process which is tightly regulated by a large number of proteins. After fusion, a similarly complex protein machinery is involved in the recycling of the vesicle membrane. In addition, many proteins modulate the amount of neurotransmitter being released, accounting at least in part for the tremendous plasticity of human brain function. Here we review the current knowledge that has been gained by the targeted disruption of genes encoding presynaptic proteins in mice. In the first chapters, we discuss those proteins which have been assigned to a specific step in the synaptic vesicle cycle. In particular, we cover proteins involved in transmitter and ion transport into synaptic vesicles, in synaptic vesicle docking and priming, in Ca2+ signaling and sensing, and in the fusion process itself. Next, we discuss proteins which are not required for neurotransmitter release, but which modulate its extent and thus most likely play a role in synaptic plasticity. Finally, we review what is known about pharmacological tools which interfere with neurotransmitter release. It can be expected that the use of transgenic mouse models will continue to increase over the coming years and that this strategy will help to finally unravel the secrets of neurotransmitter release." @default.
- W104267072 created "2016-06-24" @default.
- W104267072 creator A5031246823 @default.
- W104267072 creator A5086849150 @default.
- W104267072 date "2004-01-01" @default.
- W104267072 modified "2023-09-27" @default.
- W104267072 title "Transgenic Mouse Models in the Analysis of Neurotransmitter Release Mechanisms" @default.
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