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• W104268410 abstract "No AccessJournal of Urology1 Jul 1991The Role of Alkaline Phosphatase Isoenzymes as Tumor Markers for Testicular Germ Cell Tumors K. Koshida, A. Nishino, H. Yamamoto, T. Uchibayashi, K. Naito, H. Hisazumi, K. Hirano, Y. Hayashi, B. Wahren, and L. Andersson K. KoshidaK. Koshida More articles by this author , A. NishinoA. Nishino More articles by this author , H. YamamotoH. Yamamoto More articles by this author , T. UchibayashiT. Uchibayashi More articles by this author , K. NaitoK. Naito More articles by this author , H. HisazumiH. Hisazumi More articles by this author , K. HiranoK. Hirano More articles by this author , Y. HayashiY. Hayashi More articles by this author , B. WahrenB. Wahren More articles by this author , and L. AnderssonL. Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37714-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The role of serum alkaline phosphatase as a tumor marker for testicular germ cell disease was investigated in 26 patients with testicular seminoma and 13 with nonseminomatous germ cell testis tumors. Placental alkaline phosphatase-like enzyme was elevated in 50% of the stage I seminoma patients and in all patients with stages II to III disease. In addition, liver (tissue unspecific) alkaline phosphatase was elevated in 10 and 83% of the patients, respectively. Lactic dehydrogenase and β-human chorionic gonadotropin (β-HCG) were detected in 50 to 60% of the patients with stage I seminoma. By combining placental alkaline phosphatase-like enzyme, lactic dehydrogenase and β-HCG, 75% of the stage I and 100% of the stages II and III seminoma patients could be identified correctly. Placental alkaline phosphatase-like enzyme in serum also occurred with nonseminomatous germ cell tumor but less frequently, while liver alkaline phosphatase was not detected at all. Thus, placental alkaline phosphatase-like enzyme and liver alkaline phosphatase were predominantly determined in the serum of patients with seminoma. In studies of tumor tissues from 31 of these patients, those with normal serum placental alkaline phosphatase-like enzyme levels had significantly lower tissue placental alkaline phosphatase-like enzyme levels than patients with elevated serum levels (p <0.01). Seminoma tissues showed significantly higher levels of placental alkaline phosphatase-like enzyme and liver alkaline phosphatase than nonseminomatous germ cell tumors (p <0.01), explaining the infrequent elevation of serum placental alkaline phosphatase-like enzyme and liver alkaline phosphatase found in patients with nonseminomatous germ cell tumors. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByKoshida K, Yokoyama K, Uchibayashi T, Yamamoto H, Hirano K and Namiki M (2018) Factors Contributing to Imaging of Xenografts Using Anti-Placental Alkaline Phosphatase Monoclonal AntibodyJournal of Urology, VOL. 157, NO. 5, (1941-1945), Online publication date: 1-May-1997.Koshida K, Uchibayashi T, Yamamoto H, Yokoyama K and Hirano K (2018) A Potential Use of a Monoclonal Antibody to Placental Alkaline Phosphatase (PLAP) to Detect Lymph Node Metastases of SeminomaJournal of Urology, VOL. 155, NO. 1, (337-341), Online publication date: 1-Jan-1996. Volume 146Issue 1July 1991Page: 57-60 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordsalkaline phosphatasecarcinomatesticular neoplasmstestisisoenzymesMetricsAuthor Information K. Koshida More articles by this author A. Nishino More articles by this author H. Yamamoto More articles by this author T. Uchibayashi More articles by this author K. Naito More articles by this author H. Hisazumi More articles by this author K. Hirano More articles by this author Y. Hayashi More articles by this author B. Wahren More articles by this author L. Andersson More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W104268410 title "The Role of Alkaline Phosphatase Isoenzymes as Tumor Markers for Testicular Germ Cell Tumors" @default.
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• W104268410 doi "https://doi.org/10.1016/s0022-5347(17)37714-5" @default.
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