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- W1042742458 abstract "This chapter discusses the evolution of two butyrophenones—namely, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines The clinical results obtained with haloperidol and trifluperidol are predictable from animal data. Haloperidol and trifluperidol are indeed powerful neuroleptic drugs or major tranquilizers for man. Both the drugs are about equally active orally as parenterally. Haloperidol, longer acting than trifluperidol, is being used at daily close levels of 0.5 to 30 mg, while trifluperidol at daily doses of 0.25 to 15 mg. Both butyrophenones are being extensively used in the treatment of psychotic patients, of patients with psychomotor agitation of various etiology, in anesthesiology, and as antiemetic drugs. Fluphenazine and related phenothiazines are known to produce similar side effects. With haloperidol and trifluperidol, the incidence of chronic toxicity reactions such as jaundice, blood dyscrasias, and allergic reactions, is extremely low. More research in this field tend to further elucidate a number of problems related to the mechanism of action of neuroleptic and morphine-like drugs, the correlation between chemical structure, physical properties, and neuroleptic or morphine- like potency, and the metabolic pathways of these drugs." @default.
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- W1042742458 date "1965-01-01" @default.
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- W1042742458 title "The Evolution of The Butyrophenones, Haloperidol and Trifluperidol, From Meperidine-Like 4-Phenylpiperidines" @default.
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- W1042742458 doi "https://doi.org/10.1016/s0074-7742(08)60759-x" @default.
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