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- W104388575 abstract "Rat peritubular myoid cells in culture secrete component(s) which inhibit the activity of plasminogen activators (PA) produced by Sextoli cells, but do not inhibit the activity of plasmin. The PA inhibitor(s) (PA-I) block both urokinase-type PA (u-PA) secreted by sertoli cells under basal conditions, and tissue-type PA (t-PA) synthesized by Sertoli cells stimulated by follicle stimulating hormone or by cAMP derivatives. The approximate molecular mass of the PA-I is 55 kDa, as determined by gel exclusion chromatography; by polyacrylamide gel electrophoresis; and by reverse autography. Formation of high molecular mass complexes between PA-I and /sup 125/I-uPA is prevented by PMSF, indicating that the inhibitor-protease interaction occurs via the active center of the serine protease. Most of the peritubular cell PA-I activity can be immunoprecipitated by antibodies directed against a vascular endothelial cell PA-I. The authors conclude that peritubular myoid cells secrete one or more specific inhibitors of t-PA and u-PA. Possible functions of the PA-I in the modulation of seminiferous tubule restructuring during spermatogenesis will be discussed in relation to their previous observations that testicular PA production and secretion are greatest at discrete stages of the cycle." @default.
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- W104388575 date "1986-05-01" @default.
- W104388575 modified "2023-09-27" @default.
- W104388575 title "Testicular peritubular cells in culture secrete specific inhibitor(s) of plasminogen activators" @default.
- W104388575 hasPublicationYear "1986" @default.
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