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- W104398460 abstract "Accumulating examples have demonstrated that knock-out and knock-in mice of G-protein-coupled receptors (GPCRs) are useful in elucidating physiological functions of the receptor in vivo. GPCR knock-out and knock-in are achieved by either (1) manipulation of the endogenous locus of the receptor gene or (2) transgenic expression of the modified receptor. Historically speaking, the first generation knock-outs made the best use of homologous recombination in embryonic stem (ES) cells and their totipotency to introduce the desired mutation into the endogenous receptor locus. In the second-generation knock-outs using the Cre/loxP system, the disruption of the receptor gene is cell-type specific or region-specific but is irreversible in principle. In contrast, transgenic expression in the receptor knock-out mice of the wild-type receptor protein under a tissue- and stage-specific promoter (conditional rescue of the receptor knock-out) can be easily applied to create reversible or inducible knock-out of the receptor. This is called the third generation knock-out. In the following sections, we introduce examples of the materials and methods based on our in vivo analyses of the metabotropic glutamate receptor-subtype 1 (mGluR1)." @default.
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- W104398460 date "2004-02-09" @default.
- W104398460 modified "2023-09-23" @default.
- W104398460 title "Receptor Knock-Out and Knock-In Strategies" @default.
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- W104398460 doi "https://doi.org/10.1385/1-59259-754-8:379" @default.
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