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- W104413963 abstract "Only a minority of individuals infected with lymphatic filariasis develop clinically overt disease during their lifelong residence in endemic areas. Why this occurs is poorly understood and underscores our continuing ignorance about the pathogenesis of this disease. Here the role of the host immune response in the development and modulation of inflammatory response associated acute disease such as filarial fevers, lymphangitis and lymphadenitis that may lead to chronic lymphedema in some infected subjects and not others is examined. The role of the host immune response in the development of hydrocele, the most common form of clinical filariasis, is less clear although mechanisms of inflammation and disease are likely to be similar to that observed with acute and chronic lymphedema. Postulated mechanisms of filarial antigen-specific immune hyporesponsiveness are examined." @default.
- W104413963 created "2016-06-24" @default.
- W104413963 creator A5032632789 @default.
- W104413963 date "2005-12-23" @default.
- W104413963 modified "2023-10-01" @default.
- W104413963 title "Immune Regulation and the Spectrum of Filarial Disease" @default.
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- W104413963 doi "https://doi.org/10.1007/0-306-47661-4_11" @default.
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