FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1044203462> ?p ?o ?g. }

• W1044203462 endingPage "419" @default.
• W1044203462 startingPage "407" @default.
• W1044203462 abstract "Myocardial dysfunction is a frequent organ manifestation during septic shock and the subsequent impairment in cardiac output may result in organ hypoperfusion, requiring prompt and adequate treatment to restore cardiovascular function and reverse shock [1]. Current sepsis guidelines recommend resuscitation with intravascular fluid administration in association with inotropes and vasopressors to maintain organ perfusion [2]. Dobutamine is recommended as first-line inotropic agent and should be administered when low cardiac output or signs of hypoperfusion persist after adequate fluid resuscitation and perfusion pressure have been achieved [2]. However, the efficacy of dobutamine in patients with heart failure has not been fully demonstrated and concerns on its use are still present [3]. Although dobutamine improves perfusion and increases oxygen delivery (DO2), its impact on survival in septic shock patients is limited, with guideline recommendations based mainly on the landmark study by Rivers et al. [4]. Recently, Wilkman et al. [5] reported that the use of inotropes, particularly dobutamine, in septic shock was associated with increased 90-day mortality. In explaining the lack of outcome benefit [3, 5], several aspects need to be taken into account. First, the need of inotropic support may simply represent an expression of disease severity rather than the cause of a poor outcome. Second, whereas the treatment of impaired cardiac output should be tailored based on the etiological mechanism of the cardiovascular dysfunction, the current guidelines recommend the use of inotropes without differentiating the underlying causes of impaired left ventricular (LV) stroke volume [2, 6]. In addition, the majority of cardiovascular monitoring instruments provide data almost exclusively on cardiac output and pressures. This approach may potentially increase the number of patients who may be harmed by inotrope administration (Fig. 1). Finally, the beneficial short-term effect of enhanced contractility by cAMP-increasing drugs (e. g., dobutamine, milrinone) is, at least partly, abolished by the increased energy consumption, the worsening of ventricular relaxation and the direct cardiomyocyte toxicity [1, 7–10]." @default.
• W1044203462 created "2016-06-24" @default.
• W1044203462 creator A5022102306 @default.
• W1044203462 creator A5027370068 @default.
• W1044203462 creator A5082766868 @default.
• W1044203462 date "2014-01-01" @default.
• W1044203462 modified "2023-10-18" @default.
• W1044203462 title "Inotropic Support in the Treatment of Septic Myocardial Dysfunction: Pathophysiological Implications Supporting the Use of Levosimendan" @default.
• W1044203462 cites W1748374584 @default.
• W1044203462 cites W1954287249 @default.
• W1044203462 cites W1976561120 @default.
• W1044203462 cites W1984690823 @default.
• W1044203462 cites W1985000233 @default.
• W1044203462 cites W1987952896 @default.
• W1044203462 cites W1992536611 @default.
• W1044203462 cites W2003001618 @default.
• W1044203462 cites W2005717288 @default.
• W1044203462 cites W2020514126 @default.
• W1044203462 cites W2021222913 @default.
• W1044203462 cites W2022073422 @default.
• W1044203462 cites W2023839860 @default.
• W1044203462 cites W2025155187 @default.
• W1044203462 cites W2027694078 @default.
• W1044203462 cites W2028726566 @default.
• W1044203462 cites W2029493246 @default.
• W1044203462 cites W2033845686 @default.
• W1044203462 cites W2043513395 @default.
• W1044203462 cites W2047315175 @default.
• W1044203462 cites W2050672872 @default.
• W1044203462 cites W2059909650 @default.
• W1044203462 cites W2060423353 @default.
• W1044203462 cites W2064927551 @default.
• W1044203462 cites W2067338751 @default.
• W1044203462 cites W2071342301 @default.
• W1044203462 cites W2081875144 @default.
• W1044203462 cites W2088205404 @default.
• W1044203462 cites W2088444622 @default.
• W1044203462 cites W2091570492 @default.
• W1044203462 cites W2093440579 @default.
• W1044203462 cites W2096629979 @default.
• W1044203462 cites W2104996682 @default.
• W1044203462 cites W2120546630 @default.
• W1044203462 cites W2126364683 @default.
• W1044203462 cites W2130621776 @default.
• W1044203462 cites W2133037534 @default.
• W1044203462 cites W2133834465 @default.
• W1044203462 cites W2142798193 @default.
• W1044203462 cites W2153670019 @default.
• W1044203462 cites W2160691650 @default.
• W1044203462 cites W3023757607 @default.
• W1044203462 cites W4210712363 @default.
• W1044203462 cites W2124857470 @default.
• W1044203462 doi "https://doi.org/10.1007/978-3-319-03746-2_31" @default.
• W1044203462 hasPublicationYear "2014" @default.
• W1044203462 type Work @default.
• W1044203462 sameAs 1044203462 @default.
• W1044203462 citedByCount "3" @default.
• W1044203462 countsByYear W10442034622015 @default.
• W1044203462 countsByYear W10442034622022 @default.
• W1044203462 countsByYear W10442034622023 @default.
• W1044203462 crossrefType "book-chapter" @default.
• W1044203462 hasAuthorship W1044203462A5022102306 @default.
• W1044203462 hasAuthorship W1044203462A5027370068 @default.
• W1044203462 hasAuthorship W1044203462A5082766868 @default.
• W1044203462 hasBestOaLocation W10442034621 @default.
• W1044203462 hasConcept C126322002 @default.
• W1044203462 hasConcept C146957229 @default.
• W1044203462 hasConcept C155710745 @default.
• W1044203462 hasConcept C164705383 @default.
• W1044203462 hasConcept C177713679 @default.
• W1044203462 hasConcept C178853913 @default.
• W1044203462 hasConcept C195646399 @default.
• W1044203462 hasConcept C2777335384 @default.
• W1044203462 hasConcept C2777628635 @default.
• W1044203462 hasConcept C2778165595 @default.
• W1044203462 hasConcept C2778384902 @default.
• W1044203462 hasConcept C2778426790 @default.
• W1044203462 hasConcept C2781185063 @default.
• W1044203462 hasConcept C2781300812 @default.
• W1044203462 hasConcept C42219234 @default.
• W1044203462 hasConcept C71924100 @default.
• W1044203462 hasConceptScore W1044203462C126322002 @default.
• W1044203462 hasConceptScore W1044203462C146957229 @default.
• W1044203462 hasConceptScore W1044203462C155710745 @default.
• W1044203462 hasConceptScore W1044203462C164705383 @default.
• W1044203462 hasConceptScore W1044203462C177713679 @default.
• W1044203462 hasConceptScore W1044203462C178853913 @default.
• W1044203462 hasConceptScore W1044203462C195646399 @default.
• W1044203462 hasConceptScore W1044203462C2777335384 @default.
• W1044203462 hasConceptScore W1044203462C2777628635 @default.
• W1044203462 hasConceptScore W1044203462C2778165595 @default.
• W1044203462 hasConceptScore W1044203462C2778384902 @default.
• W1044203462 hasConceptScore W1044203462C2778426790 @default.
• W1044203462 hasConceptScore W1044203462C2781185063 @default.
• W1044203462 hasConceptScore W1044203462C2781300812 @default.
• W1044203462 hasConceptScore W1044203462C42219234 @default.
• W1044203462 hasConceptScore W1044203462C71924100 @default.
• W1044203462 hasLocation W10442034621 @default.

• next