Matches in SemOpenAlex for { <https://semopenalex.org/work/W1044851071> ?p ?o ?g. }
- W1044851071 abstract "Publisher Summary This chapter discusses the examples of the coexistence of neurotransmitters in the central nervous system (CNS). One of the most extensively studied cotransmitter relationships is that of dopamine (DA) with peptides related to cholecystokinin (CCK), a 33 amino acid peptide originally isolated from the gastrointestinal (GI) tract, where it induces pancreatic enzyme secretion. CCK is present in high concentrations in many brain regions, primarily as a sulfated octapeptide (CCK8). Using indirect immunofluorescence histochemistry together with retrograde tracing of fluorescent dyes, CCKB was shown to coexist with DA in the cell bodies and nerve terminals of a subpopulation of mesencephalic neurons. Thus, CCK may have a role in both the etiology and treatment of schizophrenia that could be related to its coexistence with DA. Norepinephrine (NE) has long been known to coexist with somatostatin in the peripheral nervous system (PNS) and with enkephalin in the PNS, CNS (locus coeruleus), and the adrenal medulla. Coexistence has also been demonstrated in the mammalian PNS and CNS with avian- and bovine-pancreatic polypeptide-like material. An area of substantial research has been the investigation of the coexistence of serotonin (5-HT) with substance P (SP) and thyrotropin-releasing hormone (TRH) both in the peripheral and central nervous systems. As with other classic neurotransmitters, γ-aminobutyric acid (GABA) has been shown t o coexist with other transmitters and neuropeptides in single neurons. Investigations of the regional localization of peptides have demonstrated a wide distribution of numerous peptides in the CNS with substantial overlap in regions, such as the pituitary and the hypothalamus. The ubiquitous distribution of peptides both in the peripheral and the central nervous systems and their potential implication in neurological diseases may provide opportunities in future drug research for the selective regulation of peptide-modulated neurons." @default.
- W1044851071 created "2016-06-24" @default.
- W1044851071 creator A5004364243 @default.
- W1044851071 creator A5023781800 @default.
- W1044851071 date "1985-01-01" @default.
- W1044851071 modified "2023-09-23" @default.
- W1044851071 title "Chapter 6. Cotransmitters in the CNS" @default.
- W1044851071 cites W1529693266 @default.
- W1044851071 cites W1571579185 @default.
- W1044851071 cites W1606587171 @default.
- W1044851071 cites W1607600798 @default.
- W1044851071 cites W1964641528 @default.
- W1044851071 cites W1964847660 @default.
- W1044851071 cites W1966741811 @default.
- W1044851071 cites W1968858188 @default.
- W1044851071 cites W1970361353 @default.
- W1044851071 cites W1970990763 @default.
- W1044851071 cites W1973255737 @default.
- W1044851071 cites W1975733536 @default.
- W1044851071 cites W1976502044 @default.
- W1044851071 cites W1977223194 @default.
- W1044851071 cites W1977776393 @default.
- W1044851071 cites W1978238621 @default.
- W1044851071 cites W1979807659 @default.
- W1044851071 cites W1981353218 @default.
- W1044851071 cites W1982719361 @default.
- W1044851071 cites W1984640897 @default.
- W1044851071 cites W1987396147 @default.
- W1044851071 cites W1987754389 @default.
- W1044851071 cites W1988094945 @default.
- W1044851071 cites W1988754907 @default.
- W1044851071 cites W1990154197 @default.
- W1044851071 cites W1991786134 @default.
- W1044851071 cites W1992303528 @default.
- W1044851071 cites W1995201487 @default.
- W1044851071 cites W1996067981 @default.
- W1044851071 cites W1996404594 @default.
- W1044851071 cites W1996961873 @default.
- W1044851071 cites W2004605737 @default.
- W1044851071 cites W2004809019 @default.
- W1044851071 cites W2005996647 @default.
- W1044851071 cites W2006772946 @default.
- W1044851071 cites W2007106869 @default.
- W1044851071 cites W2007903907 @default.
- W1044851071 cites W2009001206 @default.
- W1044851071 cites W2010579678 @default.
- W1044851071 cites W2010856500 @default.
- W1044851071 cites W2015046754 @default.
- W1044851071 cites W2023922627 @default.
- W1044851071 cites W2024681987 @default.
- W1044851071 cites W2026846735 @default.
- W1044851071 cites W2027188752 @default.
- W1044851071 cites W2029172218 @default.
- W1044851071 cites W2031376908 @default.
- W1044851071 cites W2031753690 @default.
- W1044851071 cites W2032040549 @default.
- W1044851071 cites W2032953447 @default.
- W1044851071 cites W2034832767 @default.
- W1044851071 cites W2034969383 @default.
- W1044851071 cites W2039231185 @default.
- W1044851071 cites W2040113151 @default.
- W1044851071 cites W2046245471 @default.
- W1044851071 cites W2046604017 @default.
- W1044851071 cites W2046628195 @default.
- W1044851071 cites W2046675293 @default.
- W1044851071 cites W2047869349 @default.
- W1044851071 cites W2049074524 @default.
- W1044851071 cites W2049666485 @default.
- W1044851071 cites W2051361832 @default.
- W1044851071 cites W2051365317 @default.
- W1044851071 cites W2052094974 @default.
- W1044851071 cites W2052330864 @default.
- W1044851071 cites W2054510326 @default.
- W1044851071 cites W2054590519 @default.
- W1044851071 cites W2055044131 @default.
- W1044851071 cites W2055560376 @default.
- W1044851071 cites W2057313983 @default.
- W1044851071 cites W2061296589 @default.
- W1044851071 cites W2061475155 @default.
- W1044851071 cites W2065279485 @default.
- W1044851071 cites W2066349298 @default.
- W1044851071 cites W2067060275 @default.
- W1044851071 cites W2071004111 @default.
- W1044851071 cites W2072319597 @default.
- W1044851071 cites W2074404355 @default.
- W1044851071 cites W2075007602 @default.
- W1044851071 cites W2075077190 @default.
- W1044851071 cites W2075201251 @default.
- W1044851071 cites W2076006833 @default.
- W1044851071 cites W2079728234 @default.
- W1044851071 cites W2079791307 @default.
- W1044851071 cites W2080814137 @default.
- W1044851071 cites W2083242942 @default.
- W1044851071 cites W2083854182 @default.
- W1044851071 cites W2087867929 @default.
- W1044851071 cites W2089099952 @default.
- W1044851071 cites W2090814796 @default.
- W1044851071 cites W2091621280 @default.
- W1044851071 cites W2091662811 @default.
- W1044851071 cites W2092612400 @default.