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• W1045129097 endingPage "S85" @default.
• W1045129097 startingPage "S80" @default.
• W1045129097 abstract "Hepatocellular carcinoma (HCC) is a major health problem. Mortality owing to liver cancer has increased in the past 20 years, with recent studies reporting an incidence of 780,000 cases/year. Most patients with hepatocellular carcinoma are still diagnosed at intermediate or advanced disease stages, where curative approaches are often not feasible. Among the treatment options available, the molecular targeted agent sorafenib is able to significantly increase overall survival in these patients. Afterwards, up to 7 randomized phase III clinical trials investigating other molecular therapies in the first-line and second-line settings have failed to improve survival. Potential reasons for this include intertumor heterogeneity, issues with trial design and a lack of predictive biomarkers of response. Advance in our knowledge of the human genome has provided a comprehensive picture of commonly mutated genes in patients with HCC including mutations in the TERT promoter, CTNNB1, TP53 and ARID1A along with other amplifications (FGF19, VEGFA) or homozygous deletions (p16) as the most frequent alterations. This knowledge points toward specific drivers as candidate for druggable therapies. Thus, progressive implementation of proof-of-concept and enrichment might improve results in clinical trials testing of molecular targeted agents. Ultimately, these studies are aimed at long-term to improve current standards of care and influenced clinical decision-making and practice guidelines." @default.
• W1045129097 created "2016-06-24" @default.
• W1045129097 creator A5005432402 @default.
• W1045129097 creator A5052975894 @default.
• W1045129097 date "2015-09-01" @default.
• W1045129097 modified "2023-10-08" @default.
• W1045129097 title "New molecular therapies for hepatocellular carcinoma" @default.
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• W1045129097 doi "https://doi.org/10.1016/j.clinre.2015.06.016" @default.
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• W1045129097 hasPublicationYear "2015" @default.
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