Matches in SemOpenAlex for { <https://semopenalex.org/work/W1045490680> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1045490680 endingPage "1570" @default.
- W1045490680 startingPage "1567" @default.
- W1045490680 abstract "AIM: To assess the putative involvement of NF-κB and proinflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin (IND)on cachexia.METHODS: Thirty young male BABL/c mice were divided randomly into five groups: (a) control, (b) tumor-bearing murine were inoculated subcutaneously to induce cachexia.Saline and IND were given intraperitoneally daily for 7 days from the onset of cachexia to sacrifice. Food intake and body composition were documented, serum levels of TNFα and IL-6 and activity of NF-κB in the spleen were investigated in all animals.RESULTS: Weight loss was observed in all tumor-bearing mice. By day 16, body weights of non-tumor mice were about 72 % of healthy controls (P＜0.01), and the weight of gastrocnemius was decreased by 28.7 % (P＜0.01). No difference was found between groups in food intake (P＞0.05).Gastrocnemius weight was increased markedly (P＜0.01)body weights were not significantly elevated. Tumor-bearing caused a 2-3 fold increase in serum levels of both TNF-αand IL-6 (P＜0.01). The concentration of TNF-α (P＜0.05)and IL-6 (P＜0.01) in tumor-bearing mice was reduced after of IL-6 was slightly elevated following treatment of IND 2.0tumor-bearing mice in comparison with controls in electrophoretic mobility shift assay (ENSA). NF-κB activity a higher NF-κB activity was observed in mice treated with CONCLUSION: Colon 26 adenocarcinoma cells can induce severe cancer cachexia experimentally, and the mechanism may be partially due to the enhanced TNF-αand IL-6 in tumor-bearing animals, which is controlled by NF-κB. Low dose of indomethacin alleviates the cachexia,decreases the activation of NF-κB and the serum levels of TNF-α and IL-6, and prevents body weight loss and muscle atrophy, while no further effect is gained by a higher dosage." @default.
- W1045490680 created "2016-06-24" @default.
- W1045490680 creator A5013931380 @default.
- W1045490680 creator A5016216957 @default.
- W1045490680 creator A5026448195 @default.
- W1045490680 creator A5057975875 @default.
- W1045490680 creator A5073709511 @default.
- W1045490680 creator A5076577959 @default.
- W1045490680 date "2003-01-01" @default.
- W1045490680 modified "2023-09-26" @default.
- W1045490680 title "Role of NF-κB and cytokine in experimental cancer cachexia" @default.
- W1045490680 hasPublicationYear "2003" @default.
- W1045490680 type Work @default.
- W1045490680 sameAs 1045490680 @default.
- W1045490680 citedByCount "0" @default.
- W1045490680 crossrefType "journal-article" @default.
- W1045490680 hasAuthorship W1045490680A5013931380 @default.
- W1045490680 hasAuthorship W1045490680A5016216957 @default.
- W1045490680 hasAuthorship W1045490680A5026448195 @default.
- W1045490680 hasAuthorship W1045490680A5057975875 @default.
- W1045490680 hasAuthorship W1045490680A5073709511 @default.
- W1045490680 hasAuthorship W1045490680A5076577959 @default.
- W1045490680 hasConcept C121608353 @default.
- W1045490680 hasConcept C126322002 @default.
- W1045490680 hasConcept C134018914 @default.
- W1045490680 hasConcept C147583825 @default.
- W1045490680 hasConcept C164027704 @default.
- W1045490680 hasConcept C17991360 @default.
- W1045490680 hasConcept C2776914184 @default.
- W1045490680 hasConcept C2777397205 @default.
- W1045490680 hasConcept C2777704314 @default.
- W1045490680 hasConcept C2778690821 @default.
- W1045490680 hasConcept C2780931953 @default.
- W1045490680 hasConcept C2780942790 @default.
- W1045490680 hasConcept C3020092424 @default.
- W1045490680 hasConcept C511355011 @default.
- W1045490680 hasConcept C544821477 @default.
- W1045490680 hasConcept C71924100 @default.
- W1045490680 hasConceptScore W1045490680C121608353 @default.
- W1045490680 hasConceptScore W1045490680C126322002 @default.
- W1045490680 hasConceptScore W1045490680C134018914 @default.
- W1045490680 hasConceptScore W1045490680C147583825 @default.
- W1045490680 hasConceptScore W1045490680C164027704 @default.
- W1045490680 hasConceptScore W1045490680C17991360 @default.
- W1045490680 hasConceptScore W1045490680C2776914184 @default.
- W1045490680 hasConceptScore W1045490680C2777397205 @default.
- W1045490680 hasConceptScore W1045490680C2777704314 @default.
- W1045490680 hasConceptScore W1045490680C2778690821 @default.
- W1045490680 hasConceptScore W1045490680C2780931953 @default.
- W1045490680 hasConceptScore W1045490680C2780942790 @default.
- W1045490680 hasConceptScore W1045490680C3020092424 @default.
- W1045490680 hasConceptScore W1045490680C511355011 @default.
- W1045490680 hasConceptScore W1045490680C544821477 @default.
- W1045490680 hasConceptScore W1045490680C71924100 @default.
- W1045490680 hasIssue "7" @default.
- W1045490680 hasLocation W10454906801 @default.
- W1045490680 hasOpenAccess W1045490680 @default.
- W1045490680 hasPrimaryLocation W10454906801 @default.
- W1045490680 hasRelatedWork W1505581973 @default.
- W1045490680 hasRelatedWork W1970919452 @default.
- W1045490680 hasRelatedWork W1975114552 @default.
- W1045490680 hasRelatedWork W2020163004 @default.
- W1045490680 hasRelatedWork W2089338625 @default.
- W1045490680 hasRelatedWork W2102019645 @default.
- W1045490680 hasRelatedWork W2165363238 @default.
- W1045490680 hasRelatedWork W2348358683 @default.
- W1045490680 hasRelatedWork W2350834062 @default.
- W1045490680 hasRelatedWork W2353755397 @default.
- W1045490680 hasRelatedWork W2356245841 @default.
- W1045490680 hasRelatedWork W2391780276 @default.
- W1045490680 hasRelatedWork W2410121091 @default.
- W1045490680 hasRelatedWork W2415114363 @default.
- W1045490680 hasRelatedWork W3025874136 @default.
- W1045490680 hasRelatedWork W3029566055 @default.
- W1045490680 hasRelatedWork W3030366776 @default.
- W1045490680 hasRelatedWork W3031432065 @default.
- W1045490680 hasRelatedWork W3145346676 @default.
- W1045490680 hasRelatedWork W3191009247 @default.
- W1045490680 hasVolume "9" @default.
- W1045490680 isParatext "false" @default.
- W1045490680 isRetracted "false" @default.
- W1045490680 magId "1045490680" @default.
- W1045490680 workType "article" @default.