Matches in SemOpenAlex for { <https://semopenalex.org/work/W104712367> ?p ?o ?g. }
- W104712367 endingPage "299" @default.
- W104712367 startingPage "281" @default.
- W104712367 abstract "The binding of growth factors to cell surface receptors rapidly induces a mitogenic signal transduction cascade, which results in transcriptional activation of early response genes such as fos [1,2]. This mitogenic signal transduction process involves a complex series of events, including tyrosine phosphorylation, Ras G-protein-dependent effects, activation of phospholipases, and activation of protein kinase C and other cytoplasmic serine/threonine protein kinases that transduce the mitogenic signal from the cell membrane to the cell nucleus. In addition to the rapid activation of fos transcription, there are rapid changes in phosphorylation of the Jun protein. The newly synthesized Fos protein complexes with newly phosphorylated Jun protein via leucine zipper motifs; this produces the active Fos:Jun heterodimer known as AP-1(Fos:Jun) [3,4]. AP-1(Fos:Jun) is a transcription control factor that modulates the transcription of numerous genes that contain AP-1 control elements. The activation of AP-1(Fos:Jun) in response to mitogenic stimuli occurs during the transition between the G0 phase (the resting stage of the cell cycle) and G1, phase (the stage when the cell becomes committed to undergo mitosis). This initiation of the G1 phase is followed several hours later by the activation of DNA synthesis (S phase) and eventually mitosis (M phase). This chapter focuses on the signal transduction pathways, which may connect stimulation of cell surface receptors to an important early G1 phase response, i.e., AP-1(Fos:Jun) formation via activation of fos transcription and Jun phosphorylation." @default.
- W104712367 created "2016-06-24" @default.
- W104712367 creator A5019401361 @default.
- W104712367 date "1993-01-01" @default.
- W104712367 modified "2023-10-18" @default.
- W104712367 title "Involvement of G proteins, cytoplasmic calcium, phospholipases, phospholipid-derived second messengers, and protein kinases in signal transduction from mitogenic cell surface receptors" @default.
- W104712367 cites W129757728 @default.
- W104712367 cites W1484647033 @default.
- W104712367 cites W1485105669 @default.
- W104712367 cites W1486569222 @default.
- W104712367 cites W1491415846 @default.
- W104712367 cites W1493349125 @default.
- W104712367 cites W1493863118 @default.
- W104712367 cites W1505684107 @default.
- W104712367 cites W1508152421 @default.
- W104712367 cites W1508486622 @default.
- W104712367 cites W1512390959 @default.
- W104712367 cites W1513857523 @default.
- W104712367 cites W1518781107 @default.
- W104712367 cites W1526528713 @default.
- W104712367 cites W1528325393 @default.
- W104712367 cites W1528340834 @default.
- W104712367 cites W1531280250 @default.
- W104712367 cites W1533980379 @default.
- W104712367 cites W1539582413 @default.
- W104712367 cites W1547508081 @default.
- W104712367 cites W1555993133 @default.
- W104712367 cites W1559065150 @default.
- W104712367 cites W1563821664 @default.
- W104712367 cites W1565496454 @default.
- W104712367 cites W1567527369 @default.
- W104712367 cites W1573828669 @default.
- W104712367 cites W1584978389 @default.
- W104712367 cites W1601592083 @default.
- W104712367 cites W1608134531 @default.
- W104712367 cites W1640512254 @default.
- W104712367 cites W1795153858 @default.
- W104712367 cites W1844649556 @default.
- W104712367 cites W1877216556 @default.
- W104712367 cites W1878026602 @default.
- W104712367 cites W1889390904 @default.
- W104712367 cites W1956661481 @default.
- W104712367 cites W1966831459 @default.
- W104712367 cites W1967159767 @default.
- W104712367 cites W1969280548 @default.
- W104712367 cites W1977302628 @default.
- W104712367 cites W1977472414 @default.
- W104712367 cites W1977525265 @default.
- W104712367 cites W1981810445 @default.
- W104712367 cites W1982134009 @default.
- W104712367 cites W1983501834 @default.
- W104712367 cites W1987757198 @default.
- W104712367 cites W1990401009 @default.
- W104712367 cites W1994378208 @default.
- W104712367 cites W1996093792 @default.
- W104712367 cites W1997093700 @default.
- W104712367 cites W2002623358 @default.
- W104712367 cites W2005189737 @default.
- W104712367 cites W2005529016 @default.
- W104712367 cites W2007812266 @default.
- W104712367 cites W2010403667 @default.
- W104712367 cites W2016717357 @default.
- W104712367 cites W2017733935 @default.
- W104712367 cites W2022658303 @default.
- W104712367 cites W2026625436 @default.
- W104712367 cites W2028225874 @default.
- W104712367 cites W2029128430 @default.
- W104712367 cites W2032359283 @default.
- W104712367 cites W2032923234 @default.
- W104712367 cites W2033436103 @default.
- W104712367 cites W2034225514 @default.
- W104712367 cites W2038816853 @default.
- W104712367 cites W2040857340 @default.
- W104712367 cites W2040888475 @default.
- W104712367 cites W2041104433 @default.
- W104712367 cites W2041402293 @default.
- W104712367 cites W2041561625 @default.
- W104712367 cites W2042260090 @default.
- W104712367 cites W2043590802 @default.
- W104712367 cites W2044163708 @default.
- W104712367 cites W2045925233 @default.
- W104712367 cites W2047945116 @default.
- W104712367 cites W2048784760 @default.
- W104712367 cites W2049952321 @default.
- W104712367 cites W2051111767 @default.
- W104712367 cites W2051958366 @default.
- W104712367 cites W2051958752 @default.
- W104712367 cites W2052977964 @default.
- W104712367 cites W2053286013 @default.
- W104712367 cites W2057323377 @default.
- W104712367 cites W2057345518 @default.
- W104712367 cites W2058491704 @default.
- W104712367 cites W2059485002 @default.
- W104712367 cites W2059796872 @default.
- W104712367 cites W2062170395 @default.
- W104712367 cites W2062228467 @default.
- W104712367 cites W2065553730 @default.
- W104712367 cites W2067804507 @default.