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- W104778587 abstract "FDA-approved dosing of four-factor prothrombin complex concentrate (4F-PCC) in the USA is based on an INR and weight; however, there are data suggesting that a fixed dose of 4F-PCC may be sufficient for INR reversal and hemostasis [1,2]. The objective of this study was to assess the efficacy and safety of a fixed dose of 1,500 units of 4F-PCC. Historically, warfarin reversal included a combination of factor IX complex, vitamin K, and fresh frozen plasma (FFP). Using a fixed dose of 4F-PCC may also provide significant cost savings when compared with traditional dosing." @default.
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- W104778587 date "2015-01-01" @default.
- W104778587 modified "2023-09-27" @default.
- W104778587 title "Evaluation of fixed dose four-factor prothrombin complex concentrate for warfarin reversal at a level 1 trauma center" @default.
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- W104778587 doi "https://doi.org/10.1186/cc14426" @default.
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