FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1048969015> ?p ?o ?g. }

• W1048969015 endingPage "744" @default.
• W1048969015 startingPage "737" @default.
• W1048969015 abstract "The Toll signaling pathway is one of the most important regulators of the immune response in both vertebrates and invertebrates. Herein, three novel Toll (PtToll1-3) cDNA sequences were cloned from the swimming crab, Portunus trituberculatus. PtToll1 has 1003 amino acid residues and consists of an extracellular domain containing 15 leucine-rich repeats (LRRs) and a cytoplasmic Toll/interleukin-1 receptor (TIR) domain of 139 residues. PtToll2 encodes 1196 peptides, with an extracellular domain containing 28 LRRs and a cytoplasmic TIR domain. PtToll3 is 1229 residues long and contains 26 LRRs and a cytoplasmic TIR domain. Based on sequence and phylogenetic analyses, PtToll1 distinctly clustered with almost all crustacean Tolls, except Litopenaeus vannamei Toll3. However, PtToll2 and PtToll3 were separated from most reported crustacean Tolls, which mostly clustered with Drosophila melanogaster (Dm) Toll8, L. vannamei Toll3, and DmToll6. Reverse transcription PCR and real-time quantitative PCR analyses showed that PtToll1 and PtToll3 were constitutively expressed in all tissues tested, but PtToll2 mRNA was only highly enriched in gills. Upon challenges with Vibrio alginolyticus, Candida lusitaniae, or white spot syndrome virus (WSSV), the three Tolls exhibited different responses: the PtToll1 transcript was up-regulated in response to C. lusitaniae or V. alginolyticus challenge, but did not respond to WSSV challenge; both PtToll2 and PtToll3 mRNAs were down-regulated 12 h after C. lusitaniae or V. alginolyticus infection. However, WSSV elicited the expression of PtToll2 at 6 h post-infection, but suppressed transcription of PtToll3 at 24 h post-infection. The study provides valuable data for understanding the role of Toll pathways in the host defense against microbial pathogens, which will facilitate future studies on host-pathogen interactions in crabs." @default.
• W1048969015 created "2016-06-24" @default.
• W1048969015 creator A5010806417 @default.
• W1048969015 creator A5025292981 @default.
• W1048969015 creator A5042608810 @default.
• W1048969015 creator A5049502730 @default.
• W1048969015 creator A5081461782 @default.
• W1048969015 creator A5087592842 @default.
• W1048969015 date "2015-10-01" @default.
• W1048969015 modified "2023-09-26" @default.
• W1048969015 title "Three novel Toll genes (PtToll1–3) identified from a marine crab, Portunus trituberculatus: Different tissue expression and response to pathogens" @default.
• W1048969015 cites W1971213930 @default.
• W1048969015 cites W1981014132 @default.
• W1048969015 cites W1995744610 @default.
• W1048969015 cites W2006420797 @default.
• W1048969015 cites W2010817624 @default.
• W1048969015 cites W2011593091 @default.
• W1048969015 cites W2027965015 @default.
• W1048969015 cites W2030551855 @default.
• W1048969015 cites W2032056947 @default.
• W1048969015 cites W2034394542 @default.
• W1048969015 cites W2036953322 @default.
• W1048969015 cites W2042590551 @default.
• W1048969015 cites W2053523690 @default.
• W1048969015 cites W2056162564 @default.
• W1048969015 cites W2059344622 @default.
• W1048969015 cites W2070793039 @default.
• W1048969015 cites W2071627706 @default.
• W1048969015 cites W2087080360 @default.
• W1048969015 cites W2096782178 @default.
• W1048969015 cites W2102549002 @default.
• W1048969015 cites W2107277218 @default.
• W1048969015 cites W2107997395 @default.
• W1048969015 cites W2109491705 @default.
• W1048969015 cites W2111260918 @default.
• W1048969015 cites W2116760607 @default.
• W1048969015 cites W2119747146 @default.
• W1048969015 cites W2126552441 @default.
• W1048969015 cites W2137590150 @default.
• W1048969015 cites W4240703872 @default.
• W1048969015 doi "https://doi.org/10.1016/j.fsi.2015.07.027" @default.
• W1048969015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26238349" @default.
• W1048969015 hasPublicationYear "2015" @default.
• W1048969015 type Work @default.
• W1048969015 sameAs 1048969015 @default.
• W1048969015 citedByCount "23" @default.
• W1048969015 countsByYear W10489690152016 @default.
• W1048969015 countsByYear W10489690152017 @default.
• W1048969015 countsByYear W10489690152018 @default.
• W1048969015 countsByYear W10489690152019 @default.
• W1048969015 countsByYear W10489690152020 @default.
• W1048969015 countsByYear W10489690152021 @default.
• W1048969015 countsByYear W10489690152022 @default.
• W1048969015 countsByYear W10489690152023 @default.
• W1048969015 crossrefType "journal-article" @default.
• W1048969015 hasAuthorship W1048969015A5010806417 @default.
• W1048969015 hasAuthorship W1048969015A5025292981 @default.
• W1048969015 hasAuthorship W1048969015A5042608810 @default.
• W1048969015 hasAuthorship W1048969015A5049502730 @default.
• W1048969015 hasAuthorship W1048969015A5081461782 @default.
• W1048969015 hasAuthorship W1048969015A5087592842 @default.
• W1048969015 hasConcept C104317684 @default.
• W1048969015 hasConcept C153911025 @default.
• W1048969015 hasConcept C187882448 @default.
• W1048969015 hasConcept C2776154503 @default.
• W1048969015 hasConcept C2778066766 @default.
• W1048969015 hasConcept C2778968793 @default.
• W1048969015 hasConcept C2779771762 @default.
• W1048969015 hasConcept C505870484 @default.
• W1048969015 hasConcept C523546767 @default.
• W1048969015 hasConcept C54355233 @default.
• W1048969015 hasConcept C86803240 @default.
• W1048969015 hasConcept C89423630 @default.
• W1048969015 hasConceptScore W1048969015C104317684 @default.
• W1048969015 hasConceptScore W1048969015C153911025 @default.
• W1048969015 hasConceptScore W1048969015C187882448 @default.
• W1048969015 hasConceptScore W1048969015C2776154503 @default.
• W1048969015 hasConceptScore W1048969015C2778066766 @default.
• W1048969015 hasConceptScore W1048969015C2778968793 @default.
• W1048969015 hasConceptScore W1048969015C2779771762 @default.
• W1048969015 hasConceptScore W1048969015C505870484 @default.
• W1048969015 hasConceptScore W1048969015C523546767 @default.
• W1048969015 hasConceptScore W1048969015C54355233 @default.
• W1048969015 hasConceptScore W1048969015C86803240 @default.
• W1048969015 hasConceptScore W1048969015C89423630 @default.
• W1048969015 hasFunder F4320322605 @default.
• W1048969015 hasFunder F4320323225 @default.
• W1048969015 hasFunder F4320338464 @default.
• W1048969015 hasIssue "2" @default.
• W1048969015 hasLocation W10489690151 @default.
• W1048969015 hasLocation W10489690152 @default.
• W1048969015 hasOpenAccess W1048969015 @default.
• W1048969015 hasPrimaryLocation W10489690151 @default.
• W1048969015 hasRelatedWork W1048969015 @default.
• W1048969015 hasRelatedWork W1491763484 @default.
• W1048969015 hasRelatedWork W1983580669 @default.
• W1048969015 hasRelatedWork W2014033950 @default.
• W1048969015 hasRelatedWork W2044232468 @default.

• next