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- W10495651 abstract "To understand the information flow in neural circuits, it is essential todetermine how neurons translate synaptic input into spike output. In thecerebellum, Golgi cells are the only interneurons that inhibit granule cells inthe input layer, where mossy fibre (MF) signals converge onto both celltypes. Golgi cells also receive inputs from parallel fibres (PFs, granule cellaxons) that form synaptic contacts with the molecular layer interneurons andPurkinje cells. This synaptic organisation suggests the Golgi cells may be animportant regulatory element in the cerebellar circuit. In this thesis, I usedtargeted patch-clamp recordings guided by 2-photon microscopy toexamine the synaptic input and spike output patterns of Golgi cells inanaesthetised transgenic mice. I found that Golgi cells received bursty andoccasionally rhythmic excitatory inputs and sparse inhibitory inputs in vivo.My results also revealed that Golgi cells exhibit low spontaneous firing rates,and their spiking activity can display 1 Hz rhythmicity and synchrony withmillisecond precision. Remarkably, Golgi cells usually generated only asingle spike time-locked to the stimulus by integrating multiple synapticinputs during sensory stimulation. These results suggest that Golgi cellsencode temporal information in their spikes, and will therefore transfer thismessage throughout the cerebellar network by controlling granule cell (PF)activity.Purkinje cells, the sole output neurons of the cerebellar cortex, oftendisplay large, single all-or-none synaptic responses from the strongexcitation by climbing-fibre (CF) inputs in vitro. However, the transmission atthe CF-Purkinje cell synapse in the intact brain remains poorly understood.Using whole-cell voltage clamp recordings from Purkinje cells inanaesthetised rats, I revealed that the spontaneous CF excitatorypostsynaptic currents (CF-EPSCs) can be bursty, indicating that high-frequencyolivary axonal signals are transmitted to the cerebellum in vivo." @default.
- W10495651 created "2016-06-24" @default.
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- W10495651 date "2011-07-28" @default.
- W10495651 modified "2023-09-26" @default.
- W10495651 title "Spontaneous activity and sensory integration in cerebellar neurons in vivo" @default.
- W10495651 hasPublicationYear "2011" @default.
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