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- W105117584 abstract "a spirin has come into widespread use for recurrent miscarriage as it is believed to increase blood flow to the embryo and thereby prevent miscarriage. The rationale is that aspirin may act on hitherto unrecognized thrombophilias. Pregnancy itself is a hypercoaguable state associated with increased levels of procoagulant factors [1] and decreased levels of naturally occurring anticoagulants such as protein S [2]. Microthrombi are a common finding in the placental vasculature of women with recurrent miscarriage [3]. The aim of using aspirin to prevent women with recurrent pregnancy losses from suffering additional miscarriages is entirely laudable. At the Recurrent Miscarriage Clinic at Sheba Medical Center, approximately 40% of new patients were previously treated empirically with aspirin. However, the evidence for using aspirin is limited: only one small randomized study of 54 pregnant women with unexplained recurrent spontaneous miscarriage in which aspirin was compared to placebo [4]. This review explores whether aspirin use is justified as a means of preventing pregnancy loss." @default.
- W105117584 created "2016-06-24" @default.
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- W105117584 date "2009-03-01" @default.
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- W105117584 title "Aspirin in recurrent miscarriage: is there an indication?" @default.
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