FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W105127712> ?p ?o ?g. }

• W105127712 endingPage "3404" @default.
• W105127712 startingPage "3378" @default.
• W105127712 abstract "The TNF receptor superfamily members are all type I membrane glycoproteins with typical homology in the extracellular domain of variable numbers of cysteine-rich repeats (overall homologies, 25% to 30%). In contrast, the TNF ligand superfamily members (with the exception of LT alpha) are type II membrane glycoproteins with homology to TNF in the extracellular domain (overall homologies, 20%). TNF and LT alpha are trimeric proteins and are composed of beta-strands forming a beta-jellyroll. The homology of the beta-strand regions for the TNF ligand superfamily members suggest a similar beta-sandwich structure and possible trimeric or multimeric complex formation for most or all members. A genetic linkage, as evidence for evolutionary relatedness, is found by chromosomal cluster of TNFR p80, CD30, 4–1BB, and OX40 for 1p36; TNFR p60, TNFR-RP, and CD27 for 12p13; TNF, LT alpha, and LT beta for 6 (MHC locus); CD27L and 4–1BBL for 19p13; and FASL and OX40L for 1q25. Of the TNF ligand superfamily, TNF, LT alpha, and LT beta and their receptors (TNFR p60, TNFR p80, and TNFR-RP) interact in a complex fashion of cross-binding. However, the other family members presently have a one ligand/one receptor binding principle (CD27/CD27L, CD30/CD30L, CD40/CD40L, 4–1BB/4–1BBL, OX40/gp34, and FAS/FASL). In general, the members of the TNF ligand superfamily mediate interaction between different hematopoietic cells, such as T cell/B cell, T cell/monocyte, and T cell/T cell. Signals can be transduced not only through the receptors but also through at least some of the ligands. The transduced signals can be stimulatory or inhibitory depending on the target cell or the activation state. Taken together, TNF superfamily ligands show for the immune response an involvement in the induction of cytokine secretion and the upregulation of adhesion molecules, activation antigens, and costimulatory proteins, all known to amplify stimulatory and regulatory signals. On the other hand, differences in the distribution, kinetics of induction, and requirements for induction support a defined role for each of the ligands for T-cell-mediated immune responses. The shedding of members of the TNF receptor superfamily could limit the signals mediated by the corresponding ligands as a functional regulatory mechanism. Induction of cytotoxic cell death, observed for TNF, LT alpha, CD30L, CD95L, and 4–1BBL, is another common functional feature of this cytokine family. Further studies have to identify unique versus redundant biologic and physiologic functions for each of the TNF superfamily ligands.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W105127712 created "2016-06-24" @default.
• W105127712 creator A5009580916 @default.
• W105127712 creator A5023656781 @default.
• W105127712 date "1995-06-15" @default.
• W105127712 modified "2023-10-13" @default.
• W105127712 title "Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas" @default.
• W105127712 doi "https://doi.org/10.1182/blood.v85.12.3378.bloodjournal85123378" @default.
• W105127712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7780126" @default.
• W105127712 hasPublicationYear "1995" @default.
• W105127712 type Work @default.
• W105127712 sameAs 105127712 @default.
• W105127712 citedByCount "429" @default.
• W105127712 countsByYear W1051277122012 @default.
• W105127712 countsByYear W1051277122013 @default.
• W105127712 countsByYear W1051277122014 @default.
• W105127712 countsByYear W1051277122015 @default.
• W105127712 countsByYear W1051277122016 @default.
• W105127712 countsByYear W1051277122017 @default.
• W105127712 countsByYear W1051277122018 @default.
• W105127712 countsByYear W1051277122019 @default.
• W105127712 countsByYear W1051277122021 @default.
• W105127712 countsByYear W1051277122022 @default.
• W105127712 countsByYear W1051277122023 @default.
• W105127712 crossrefType "journal-article" @default.
• W105127712 hasAuthorship W105127712A5009580916 @default.
• W105127712 hasAuthorship W105127712A5023656781 @default.
• W105127712 hasBestOaLocation W1051277121 @default.
• W105127712 hasConcept C149774189 @default.
• W105127712 hasConcept C153911025 @default.
• W105127712 hasConcept C170493617 @default.
• W105127712 hasConcept C17991360 @default.
• W105127712 hasConcept C197462201 @default.
• W105127712 hasConcept C203014093 @default.
• W105127712 hasConcept C54355233 @default.
• W105127712 hasConcept C86803240 @default.
• W105127712 hasConcept C91682701 @default.
• W105127712 hasConcept C95444343 @default.
• W105127712 hasConceptScore W105127712C149774189 @default.
• W105127712 hasConceptScore W105127712C153911025 @default.
• W105127712 hasConceptScore W105127712C170493617 @default.
• W105127712 hasConceptScore W105127712C17991360 @default.
• W105127712 hasConceptScore W105127712C197462201 @default.
• W105127712 hasConceptScore W105127712C203014093 @default.
• W105127712 hasConceptScore W105127712C54355233 @default.
• W105127712 hasConceptScore W105127712C86803240 @default.
• W105127712 hasConceptScore W105127712C91682701 @default.
• W105127712 hasConceptScore W105127712C95444343 @default.
• W105127712 hasIssue "12" @default.
• W105127712 hasLocation W1051277121 @default.
• W105127712 hasOpenAccess W105127712 @default.
• W105127712 hasPrimaryLocation W1051277121 @default.
• W105127712 hasRelatedWork W1850522356 @default.
• W105127712 hasRelatedWork W1982280050 @default.
• W105127712 hasRelatedWork W2013831675 @default.
• W105127712 hasRelatedWork W2027991517 @default.
• W105127712 hasRelatedWork W2065181541 @default.
• W105127712 hasRelatedWork W2087712459 @default.
• W105127712 hasRelatedWork W2173333770 @default.
• W105127712 hasRelatedWork W4253079783 @default.
• W105127712 hasRelatedWork W65425793 @default.
• W105127712 hasRelatedWork W756474329 @default.
• W105127712 hasVolume "85" @default.
• W105127712 isParatext "false" @default.
• W105127712 isRetracted "false" @default.
• W105127712 magId "105127712" @default.
• W105127712 workType "article" @default.