Matches in SemOpenAlex for { <https://semopenalex.org/work/W1051312076> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1051312076 endingPage "304" @default.
- W1051312076 startingPage "298" @default.
- W1051312076 abstract "Recent evidence has shown that either intraventricular or intrahippocampal injection of the NMDA antagonist D-2-amino-5-phosphonovalerate (AP-5) produces a spatial learning deficit. This deficit is similar to that observed in aged animals. The spatial learning capacity of aged rats could, then, be related to changes in the status of hippocampal NMDA receptors. This study assessed hippocampal NMDA receptor binding in young and aged rats using the potent NMDA antagonist 3H [(±)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid (CPP). Initial characterization experiments indicated that 3H-CPP bound selectively to a class of receptors in hippocampal tissue with high affinity (39.5 nM). The 3H-CPP receptor binding capacity was significantly reduced in experimentally naive aged rats (24–25 months) as compared with young animals (5 months). A comparable reduction in 3H-CPP binding was found in a comparison of aged and young rats that had been trained on a spatial task in the Morris water maze. Furthermore, the reduction in 3H-CPP binding was correlated with the severity of the learning deficit present within the aged group. It was concluded that a reduction in hippocampal NMDA sites, as measured by 3H-CPP binding, may contribute to the emergence of cognitive deficits in aged animals." @default.
- W1051312076 created "2016-06-24" @default.
- W1051312076 creator A5028703965 @default.
- W1051312076 creator A5034738462 @default.
- W1051312076 creator A5058840976 @default.
- W1051312076 date "1990-09-01" @default.
- W1051312076 modified "2023-10-13" @default.
- W1051312076 title "Hippocampal 3H-CPP binding and spatial learning deficits in aged rats" @default.
- W1051312076 cites W1507370673 @default.
- W1051312076 cites W1567544633 @default.
- W1051312076 cites W1775749144 @default.
- W1051312076 cites W1970377013 @default.
- W1051312076 cites W1970393142 @default.
- W1051312076 cites W1977047599 @default.
- W1051312076 cites W1977709017 @default.
- W1051312076 cites W1978018256 @default.
- W1051312076 cites W1989526036 @default.
- W1051312076 cites W2009782005 @default.
- W1051312076 cites W2011999599 @default.
- W1051312076 cites W2014212152 @default.
- W1051312076 cites W2017169966 @default.
- W1051312076 cites W2023349854 @default.
- W1051312076 cites W2025801062 @default.
- W1051312076 cites W2026767130 @default.
- W1051312076 cites W2032261379 @default.
- W1051312076 cites W2065159884 @default.
- W1051312076 cites W2075689055 @default.
- W1051312076 cites W2103861118 @default.
- W1051312076 cites W2106625755 @default.
- W1051312076 cites W2126974689 @default.
- W1051312076 cites W2150578849 @default.
- W1051312076 cites W2152663903 @default.
- W1051312076 cites W4238414588 @default.
- W1051312076 cites W4251605594 @default.
- W1051312076 cites W4255276575 @default.
- W1051312076 cites W771163182 @default.
- W1051312076 cites W808369328 @default.
- W1051312076 doi "https://doi.org/10.3758/bf03327247" @default.
- W1051312076 hasPublicationYear "1990" @default.
- W1051312076 type Work @default.
- W1051312076 sameAs 1051312076 @default.
- W1051312076 citedByCount "56" @default.
- W1051312076 countsByYear W10513120762012 @default.
- W1051312076 countsByYear W10513120762013 @default.
- W1051312076 countsByYear W10513120762014 @default.
- W1051312076 countsByYear W10513120762017 @default.
- W1051312076 countsByYear W10513120762020 @default.
- W1051312076 countsByYear W10513120762023 @default.
- W1051312076 crossrefType "journal-article" @default.
- W1051312076 hasAuthorship W1051312076A5028703965 @default.
- W1051312076 hasAuthorship W1051312076A5034738462 @default.
- W1051312076 hasAuthorship W1051312076A5058840976 @default.
- W1051312076 hasBestOaLocation W10513120761 @default.
- W1051312076 hasConcept C126322002 @default.
- W1051312076 hasConcept C134018914 @default.
- W1051312076 hasConcept C148762608 @default.
- W1051312076 hasConcept C15744967 @default.
- W1051312076 hasConcept C169760540 @default.
- W1051312076 hasConcept C170493617 @default.
- W1051312076 hasConcept C185592680 @default.
- W1051312076 hasConcept C2776885963 @default.
- W1051312076 hasConcept C2781161787 @default.
- W1051312076 hasConcept C44752575 @default.
- W1051312076 hasConcept C67018056 @default.
- W1051312076 hasConcept C71924100 @default.
- W1051312076 hasConceptScore W1051312076C126322002 @default.
- W1051312076 hasConceptScore W1051312076C134018914 @default.
- W1051312076 hasConceptScore W1051312076C148762608 @default.
- W1051312076 hasConceptScore W1051312076C15744967 @default.
- W1051312076 hasConceptScore W1051312076C169760540 @default.
- W1051312076 hasConceptScore W1051312076C170493617 @default.
- W1051312076 hasConceptScore W1051312076C185592680 @default.
- W1051312076 hasConceptScore W1051312076C2776885963 @default.
- W1051312076 hasConceptScore W1051312076C2781161787 @default.
- W1051312076 hasConceptScore W1051312076C44752575 @default.
- W1051312076 hasConceptScore W1051312076C67018056 @default.
- W1051312076 hasConceptScore W1051312076C71924100 @default.
- W1051312076 hasIssue "3" @default.
- W1051312076 hasLocation W10513120761 @default.
- W1051312076 hasOpenAccess W1051312076 @default.
- W1051312076 hasPrimaryLocation W10513120761 @default.
- W1051312076 hasRelatedWork W1992949974 @default.
- W1051312076 hasRelatedWork W1994475466 @default.
- W1051312076 hasRelatedWork W2013880564 @default.
- W1051312076 hasRelatedWork W2018213389 @default.
- W1051312076 hasRelatedWork W2032398857 @default.
- W1051312076 hasRelatedWork W2044141036 @default.
- W1051312076 hasRelatedWork W2096397785 @default.
- W1051312076 hasRelatedWork W2355653291 @default.
- W1051312076 hasRelatedWork W2381750903 @default.
- W1051312076 hasRelatedWork W4313523880 @default.
- W1051312076 hasVolume "18" @default.
- W1051312076 isParatext "false" @default.
- W1051312076 isRetracted "false" @default.
- W1051312076 magId "1051312076" @default.
- W1051312076 workType "article" @default.