FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W10533360> ?p ?o ?g. }

• W10533360 endingPage "49" @default.
• W10533360 startingPage "217" @default.
• W10533360 abstract "The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain are N-terminally truncated forms: ANP (4-28) and ANP (5-28). The primary structure of BNP varies considerably among species, whereas that of CNP is highly conserved. ANP, BNP, and CNP are distributed in discrete brain regions, although the distribution varies in different species. Few immunohistochemical studies have so far been performed on BNP and CNP. There are three subtypes of receptors: ANP-A and ANP-B, which are bioactive, and the C receptor, which does not seem to be directly related to bioactivity. In the rat, the major subtype of ANP receptor in the CNS is the ANP-B receptor, based on the results of Northern blotting. Since the ligand for ANP-B receptor is CNP, the CNP-ANP-B receptor system may be most important, at least in rat brain. It is still unknown whether or not a specific receptor for BNP exists in central or peripheral tissues. Further studies should clarify the exact localization of ANP, BNP, and CNP and the three receptor subtypes in the CNS. Although natriuretic peptides and their receptors are distributed widely in the CNS, the AV3V regions, basal medial hypothalamus, brainstem, and circumventricular organs are the most prominent sites. This suggests an important physiological role of the natriuretic peptide system in the central control of cardiovascular homeostasis. The natriuretic peptide system seems to be involved in the regulation of water and salt intake, blood pressure, and secretion of vasopressin in the direction of reducing body fluid and lowering blood pressure. Such actions of natriuretic peptides are antagonistic to the central actions of angiotensin II (AII). In fact, the distribution of ANP and AII and their receptors in the CNS overlaps considerably. It is highly likely, therefore, that the central natriuretic peptide system and the renin-angiotensin system play important roles in the central control of cardiovascular and body fluid homeostasis in opposite directions. The natriuretic peptide system may also be involved in neuroendocrine control and some other CNS functions, although the physiological significance of these actions is less clear at the present time. It is now clear that there is considerable plasticity in the regulation of natriuretic peptides and their receptors.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W10533360 created "2016-06-24" @default.
• W10533360 creator A5012591536 @default.
• W10533360 creator A5033980070 @default.
• W10533360 creator A5077665206 @default.
• W10533360 date "1992-07-01" @default.
• W10533360 modified "2023-09-27" @default.
• W10533360 title "The natriuretic peptide system in the brain: implications in the central control of cardiovascular and neuroendocrine functions." @default.
• W10533360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1334000" @default.
• W10533360 hasPublicationYear "1992" @default.
• W10533360 type Work @default.
• W10533360 sameAs 10533360 @default.
• W10533360 citedByCount "48" @default.
• W10533360 countsByYear W105333602012 @default.
• W10533360 countsByYear W105333602013 @default.
• W10533360 countsByYear W105333602014 @default.
• W10533360 countsByYear W105333602016 @default.
• W10533360 countsByYear W105333602017 @default.
• W10533360 crossrefType "journal-article" @default.
• W10533360 hasAuthorship W10533360A5012591536 @default.
• W10533360 hasAuthorship W10533360A5033980070 @default.
• W10533360 hasAuthorship W10533360A5077665206 @default.
• W10533360 hasConcept C126322002 @default.
• W10533360 hasConcept C134018914 @default.
• W10533360 hasConcept C170493617 @default.
• W10533360 hasConcept C2775846464 @default.
• W10533360 hasConcept C2775915353 @default.
• W10533360 hasConcept C2777003273 @default.
• W10533360 hasConcept C2777619780 @default.
• W10533360 hasConcept C2778069365 @default.
• W10533360 hasConcept C2778198053 @default.
• W10533360 hasConcept C3156946 @default.
• W10533360 hasConcept C529278444 @default.
• W10533360 hasConcept C71924100 @default.
• W10533360 hasConcept C86803240 @default.
• W10533360 hasConcept C8741621 @default.
• W10533360 hasConceptScore W10533360C126322002 @default.
• W10533360 hasConceptScore W10533360C134018914 @default.
• W10533360 hasConceptScore W10533360C170493617 @default.
• W10533360 hasConceptScore W10533360C2775846464 @default.
• W10533360 hasConceptScore W10533360C2775915353 @default.
• W10533360 hasConceptScore W10533360C2777003273 @default.
• W10533360 hasConceptScore W10533360C2777619780 @default.
• W10533360 hasConceptScore W10533360C2778069365 @default.
• W10533360 hasConceptScore W10533360C2778198053 @default.
• W10533360 hasConceptScore W10533360C3156946 @default.
• W10533360 hasConceptScore W10533360C529278444 @default.
• W10533360 hasConceptScore W10533360C71924100 @default.
• W10533360 hasConceptScore W10533360C86803240 @default.
• W10533360 hasConceptScore W10533360C8741621 @default.
• W10533360 hasIssue "3" @default.
• W10533360 hasLocation W105333601 @default.
• W10533360 hasOpenAccess W10533360 @default.
• W10533360 hasPrimaryLocation W105333601 @default.
• W10533360 hasRelatedWork W10533360 @default.
• W10533360 hasRelatedWork W1968130104 @default.
• W10533360 hasRelatedWork W1969677127 @default.
• W10533360 hasRelatedWork W1972033663 @default.
• W10533360 hasRelatedWork W1998443384 @default.
• W10533360 hasRelatedWork W2050961361 @default.
• W10533360 hasRelatedWork W2082400577 @default.
• W10533360 hasRelatedWork W2153348972 @default.
• W10533360 hasRelatedWork W2327185741 @default.
• W10533360 hasRelatedWork W3140667117 @default.
• W10533360 hasVolume "13" @default.
• W10533360 isParatext "false" @default.
• W10533360 isRetracted "false" @default.
• W10533360 magId "10533360" @default.
• W10533360 workType "article" @default.