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• W105417710 startingPage "265" @default.
• W105417710 abstract "We are not in a position to say yet what the main function(s) of the apicomplexan plastid is, nor whether it is a realistic target for therapeutics; after all, one could argue it has lain undetected throughout the long quest for antimalarials this century without signaling its presence by the dramatic effect of some specific inhibitor. Thus, to review the effect of antibiotics on the malarial plastid organelle might justifiably be considered premature at present, although this is not the first of its kind (1–5). On the other hand, progress promises to be swift because the ongoing malaria genome sequencing project has the potential to completely describe the organelle’s functions within the next year or two. Moreover, the signs are promising that this “new found” organelle will provide novel targets because unforeseen metabolic pathways centered on the plastid have come to light already from scrutiny of the growing chromosomal sequence database (6). It is reasonable, then, to hope that specialized pathways found to operate within the plastid compartment might lend themselves to disruption, with lethal consequences for the organism and minimal effects on the host." @default.
• W105417710 created "2016-06-24" @default.
• W105417710 creator A5057053588 @default.
• W105417710 creator A5069594586 @default.
• W105417710 date "2001-01-01" @default.
• W105417710 modified "2023-09-23" @default.
• W105417710 title "Antibiotics and the Plasmodial Plastid Organelle" @default.
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