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- W1054360679 endingPage "131" @default.
- W1054360679 startingPage "103" @default.
- W1054360679 abstract "Advances in supportive care have led to significant improvements in hematopoietic cell transplant (HCT) outcomes over the last decade. This has led to performance of significantly more alternative donor HCTs for a wide variety of nonmalignant diseases, including T-cell and phagocyte primary immunodeficiencies, hemoglobinopathies, bone marrow failure syndromes, and metabolic syndromes. However, these children often have relatively intact immune systems at the time of HCT and thus require increased pre-HCT immunoablation to prevent graft rejection. This often leads to delays in post-HCT immune reconstitution, which in turn is associated with significant opportunistic infections. There is also evidence that certain opportunistic infections may play a role in the triggering of alloreactivity and graft-versus-host disease (GVHD). Since GVHD is another significant component of TRM following allogeneic HCT, further understanding of the interplay between opportunistic infections and initiation of GVHD may provide another avenue towards making HCT a safer procedure with improved overall outcomes. The wide spectrum of opportunistic infections encountered in HCT patients, including bacterial, viral, fungal, and protozoal infections, as well as recommendations for post-HCT vaccinations, are discussed here." @default.
- W1054360679 created "2016-06-24" @default.
- W1054360679 creator A5047178145 @default.
- W1054360679 creator A5056810823 @default.
- W1054360679 date "2013-10-15" @default.
- W1054360679 modified "2023-09-23" @default.
- W1054360679 title "Opportunistic Infections in Pediatric Blood and Marrow Transplantation" @default.
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