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- W105520125 abstract "Forty-eight hours of postoperation light deprivation (LD) has been found to produce complete and permanent behavioral recovery of function from neglect induced by unilateral lesions of medial agranular cortex (AGm) in rats. The two experiments in the present study parametrically examined the postoperation delay prior to LD and the duration of LD necessary to produce recovery from severe neglect. Subjects in both experiments received unilateral AGm lesions and were tested for the degree of neglect of visual, tactile, and auditory stimuli prior to and after experiencing LD. The results of the study of delay of LD indicated that LD administered 4 h postsurgery produced dramatic immediate recovery from severe neglect, and the recovery lasted for the duration of behavioral testing (3 weeks) following LD. The longer delay groups (52 and 100 h) and the no-manipulation controls did not demonstrate behavioral recovery. The 28-h delay group demonstrated an intermediate effect following LD. The results of the study of duration of LD indicated that the therapeutic effect of LD was duration dependent. Forty-eight hours of LD produced a significant reduction in the severity of neglect, but shorter durations (4 and 24 h) did not. The results of the present study indicate that a critical postoperative period exists in which LD must be initiated in order to produce recovery from severe neglect and that LD has to be administered for a period of at least 24 h to produce any evidence of recovery of function. These findings may have clinical implications for the treatment of neglect in humans." @default.
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- W105520125 title "Effects of delay and duration of light deprivation on recovery of function from neglect induced by unilateral medial agranular prefrontal cortex lesions in rats" @default.
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