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- W105702944 abstract "ABSTRACT Twenty mg of d-amphetamine induced an improvement, a worsening or failed to change psychosis in 45 drug-free schizophrenic patients. Preinfusion psychosis and CSF MHPG levels were related to clinical change following d-amphetamine. Chronic pimozide pretreatment decreased psychotic behavioral changes following a second d-amphetamine infusion. Although increases in activation and euphoria were not diminished, the d-amphetamine-induced sleep disturbance was prevented by chronic pimozide pretreatment. Twelve patients received a repeat d-amphetamine infusion seven days after pimozide withdrawal which did not indicate pimozide-induced DA receptor supersensitivity. Lithium pretreatment in seventeen patients did not affect psychotic behavior changes following d-amphetamine but attenuated the activation-euphoria cluster changes." @default.
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- W105702944 date "1981-01-01" @default.
- W105702944 modified "2023-09-27" @default.
- W105702944 title "d-AMPHETAMINE AND SCHIZOPHRENIA: BEHAVIORAL, PHARMACOLOGICAL AND PHYSIOLOGICAL EVALUATIONS" @default.
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- W105702944 doi "https://doi.org/10.1016/b978-0-08-026382-3.50009-8" @default.
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