FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W105781282> ?p ?o ?g. }

• W105781282 endingPage "72" @default.
• W105781282 startingPage "257" @default.
• W105781282 abstract "Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common craniofacial developmental defect. Recent segregation analyses have suggested that major genes play a role in the etiology of CL/P. Linkage to 22 candidate genes was tested in 11 multigenerational families with CL/P, and 21 of these candidates were excluded. APOC2, 19q13.1, which is linked to the proto-oncogene BCL3, gave suggestive evidence for linkage to CL/P. The study was expanded to include a total of 39 multigenerational CL/P families. Linkage was tested in all families, using an anonymous marker, D19S178, and intragenic markers in BCL3 and APOC2. Linkage was tested under two models, autosomal dominant with reduced penetrance and affecteds only. Homogeneity testing on the two-point data gave evidence of heterogeneity at APOC2 under the affecteds-only model. Both models showed evidence of heterogeneity, with 43% of families linked at zero recombination to BCL3 when marker data from BCL3 and APOC2 were included. A maximum multipoint LOD score of 7.00 at BCL3 was found among the 17 families that had posterior probabilities > = 50% in favor of linkage. The transmission disequilibrium test provided additional evidence for linkage with the 3 allele of BCL3 more often transmitted to affected children. These results suggest that BCL3, or a nearby gene, plays a role in the etiology of CL/P in some families." @default.
• W105781282 created "2016-06-24" @default.
• W105781282 creator A5001750018 @default.
• W105781282 creator A5002115964 @default.
• W105781282 creator A5006802038 @default.
• W105781282 creator A5024550847 @default.
• W105781282 creator A5026572099 @default.
• W105781282 creator A5030596121 @default.
• W105781282 creator A5030684064 @default.
• W105781282 creator A5038897253 @default.
• W105781282 creator A5067497013 @default.
• W105781282 creator A5083281030 @default.
• W105781282 date "1995-08-01" @default.
• W105781282 modified "2023-09-23" @default.
• W105781282 title "Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families." @default.
• W105781282 cites W1542836032 @default.
• W105781282 cites W1543868019 @default.
• W105781282 cites W1560662087 @default.
• W105781282 cites W1577966599 @default.
• W105781282 cites W1594615692 @default.
• W105781282 cites W16450641 @default.
• W105781282 cites W1940201944 @default.
• W105781282 cites W1963641861 @default.
• W105781282 cites W1965595828 @default.
• W105781282 cites W1968299822 @default.
• W105781282 cites W1979949441 @default.
• W105781282 cites W1982998146 @default.
• W105781282 cites W1992387053 @default.
• W105781282 cites W2015197182 @default.
• W105781282 cites W2017428806 @default.
• W105781282 cites W2023609566 @default.
• W105781282 cites W2032869234 @default.
• W105781282 cites W2045793427 @default.
• W105781282 cites W2049600496 @default.
• W105781282 cites W2088545432 @default.
• W105781282 cites W2103695168 @default.
• W105781282 cites W2105743874 @default.
• W105781282 cites W2109498818 @default.
• W105781282 cites W2122559781 @default.
• W105781282 cites W2128508005 @default.
• W105781282 cites W2159548713 @default.
• W105781282 cites W2414647879 @default.
• W105781282 cites W262582758 @default.
• W105781282 cites W3152402756 @default.
• W105781282 cites W63518042 @default.
• W105781282 cites W8694186 @default.
• W105781282 cites W34241000 @default.
• W105781282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1801552" @default.
• W105781282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7668251" @default.
• W105781282 hasPublicationYear "1995" @default.
• W105781282 type Work @default.
• W105781282 sameAs 105781282 @default.
• W105781282 citedByCount "41" @default.
• W105781282 countsByYear W1057812822015 @default.
• W105781282 countsByYear W1057812822016 @default.
• W105781282 countsByYear W1057812822019 @default.
• W105781282 crossrefType "journal-article" @default.
• W105781282 hasAuthorship W105781282A5001750018 @default.
• W105781282 hasAuthorship W105781282A5002115964 @default.
• W105781282 hasAuthorship W105781282A5006802038 @default.
• W105781282 hasAuthorship W105781282A5024550847 @default.
• W105781282 hasAuthorship W105781282A5026572099 @default.
• W105781282 hasAuthorship W105781282A5030596121 @default.
• W105781282 hasAuthorship W105781282A5030684064 @default.
• W105781282 hasAuthorship W105781282A5038897253 @default.
• W105781282 hasAuthorship W105781282A5067497013 @default.
• W105781282 hasAuthorship W105781282A5083281030 @default.
• W105781282 hasConcept C104317684 @default.
• W105781282 hasConcept C126322002 @default.
• W105781282 hasConcept C127716648 @default.
• W105781282 hasConcept C137627325 @default.
• W105781282 hasConcept C142870003 @default.
• W105781282 hasConcept C180754005 @default.
• W105781282 hasConcept C197754878 @default.
• W105781282 hasConcept C200544954 @default.
• W105781282 hasConcept C2776885448 @default.
• W105781282 hasConcept C31266012 @default.
• W105781282 hasConcept C35605836 @default.
• W105781282 hasConcept C54355233 @default.
• W105781282 hasConcept C69991583 @default.
• W105781282 hasConcept C71924100 @default.
• W105781282 hasConcept C84597430 @default.
• W105781282 hasConcept C86803240 @default.
• W105781282 hasConceptScore W105781282C104317684 @default.
• W105781282 hasConceptScore W105781282C126322002 @default.
• W105781282 hasConceptScore W105781282C127716648 @default.
• W105781282 hasConceptScore W105781282C137627325 @default.
• W105781282 hasConceptScore W105781282C142870003 @default.
• W105781282 hasConceptScore W105781282C180754005 @default.
• W105781282 hasConceptScore W105781282C197754878 @default.
• W105781282 hasConceptScore W105781282C200544954 @default.
• W105781282 hasConceptScore W105781282C2776885448 @default.
• W105781282 hasConceptScore W105781282C31266012 @default.
• W105781282 hasConceptScore W105781282C35605836 @default.
• W105781282 hasConceptScore W105781282C54355233 @default.
• W105781282 hasConceptScore W105781282C69991583 @default.
• W105781282 hasConceptScore W105781282C71924100 @default.
• W105781282 hasConceptScore W105781282C84597430 @default.

• next