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- W1058162275 endingPage "577" @default.
- W1058162275 startingPage "557" @default.
- W1058162275 abstract "Hepatitis C virus (HCV) and molecular methods are inextricably linked, in history and in clinical practice. This virus was the first to be identified with molecular methods, and nucleic acid tests (NATs) have become fundamentally important in the diagnosis and therapeutic management of the chronic infections it causes. Rates of spontaneous virus clearance are highest in acutely infected individuals who manifest signs of hepatitis, suggesting that an early immune response may be protective. Risk factors for disease progression include diseases or behaviors that induce additional hepatic injury (such as concomitant hepatitis B virus [HBV] infection and alcohol consumption) or impair antiviral immunity (such as HIV infection). Treatment for HCV infection has undergone significant evolution in regard to available agents, duration, and dosing strategy. Important concepts in regard to testing for acute HCV infection are that (i) serology and RNA assessment should both be performed and (ii) testing should be undertaken at multiple time points before exclusion of the diagnosis. Given the asymptomatic nature of most acute HCV infections, the majority of patients will present symptomatically, in the chronic phase. The approval of STAT-C drugs has the potential to vastly improve treatment efficacy and concomitantly impose a new paradigm for therapeutic monitoring. The effect of telaprevir on the performance of viral load testing and the necessity for additional tests such as resistance assays remains to be determined." @default.
- W1058162275 created "2016-06-24" @default.
- W1058162275 creator A5003113997 @default.
- W1058162275 creator A5045164457 @default.
- W1058162275 date "2011-06-10" @default.
- W1058162275 modified "2023-09-23" @default.
- W1058162275 title "Molecular Detection and Characterization of Hepatitis C Virus" @default.
- W1058162275 cites W1523532924 @default.
- W1058162275 cites W1663147232 @default.
- W1058162275 cites W1907902047 @default.
- W1058162275 cites W1970053808 @default.
- W1058162275 cites W1973428945 @default.
- W1058162275 cites W1977028768 @default.
- W1058162275 cites W1980390916 @default.
- W1058162275 cites W1982350119 @default.
- W1058162275 cites W1982433898 @default.
- W1058162275 cites W1982810241 @default.
- W1058162275 cites W1984165562 @default.
- W1058162275 cites W1985241178 @default.
- W1058162275 cites W1986498353 @default.
- W1058162275 cites W1989058813 @default.
- W1058162275 cites W1992239172 @default.
- W1058162275 cites W1996434966 @default.
- W1058162275 cites W1998342780 @default.
- W1058162275 cites W1998346806 @default.
- W1058162275 cites W1998859748 @default.
- W1058162275 cites W2000788295 @default.
- W1058162275 cites W2001467294 @default.
- W1058162275 cites W2004360699 @default.
- W1058162275 cites W2004827278 @default.
- W1058162275 cites W2006309458 @default.
- W1058162275 cites W2008413358 @default.
- W1058162275 cites W2014692145 @default.
- W1058162275 cites W2016414950 @default.
- W1058162275 cites W2018446644 @default.
- W1058162275 cites W2019672317 @default.
- W1058162275 cites W2021848579 @default.
- W1058162275 cites W2023599537 @default.
- W1058162275 cites W2024043429 @default.
- W1058162275 cites W2024049300 @default.
- W1058162275 cites W2027545702 @default.
- W1058162275 cites W2027853774 @default.
- W1058162275 cites W2027912196 @default.
- W1058162275 cites W2028207409 @default.
- W1058162275 cites W2031634356 @default.
- W1058162275 cites W2033684892 @default.
- W1058162275 cites W2036697711 @default.
- W1058162275 cites W2037727076 @default.
- W1058162275 cites W2043068610 @default.
- W1058162275 cites W2043825818 @default.
- W1058162275 cites W2045427953 @default.
- W1058162275 cites W2045531679 @default.
- W1058162275 cites W2047208492 @default.
- W1058162275 cites W2048396008 @default.
- W1058162275 cites W2055601327 @default.
- W1058162275 cites W2057075704 @default.
- W1058162275 cites W2058361955 @default.
- W1058162275 cites W2059022314 @default.
- W1058162275 cites W2060898835 @default.
- W1058162275 cites W2061967212 @default.
- W1058162275 cites W2062135550 @default.
- W1058162275 cites W2071586067 @default.
- W1058162275 cites W2077908721 @default.
- W1058162275 cites W2078159905 @default.
- W1058162275 cites W2080223423 @default.
- W1058162275 cites W2083950752 @default.
- W1058162275 cites W2086968381 @default.
- W1058162275 cites W2090153322 @default.
- W1058162275 cites W2093355675 @default.
- W1058162275 cites W2096064188 @default.
- W1058162275 cites W2096390005 @default.
- W1058162275 cites W2097164244 @default.
- W1058162275 cites W2097604984 @default.
- W1058162275 cites W2100531374 @default.
- W1058162275 cites W2103130225 @default.
- W1058162275 cites W2105605655 @default.
- W1058162275 cites W2107175809 @default.
- W1058162275 cites W2107188441 @default.
- W1058162275 cites W2108474798 @default.
- W1058162275 cites W2111044696 @default.
- W1058162275 cites W2111316755 @default.
- W1058162275 cites W2111996375 @default.
- W1058162275 cites W2112475505 @default.
- W1058162275 cites W2112876622 @default.
- W1058162275 cites W2113383235 @default.
- W1058162275 cites W2113869422 @default.
- W1058162275 cites W2115413971 @default.
- W1058162275 cites W2116083731 @default.
- W1058162275 cites W2116590783 @default.
- W1058162275 cites W2119885012 @default.
- W1058162275 cites W2121595515 @default.
- W1058162275 cites W2122153421 @default.
- W1058162275 cites W2122431370 @default.
- W1058162275 cites W2124528668 @default.
- W1058162275 cites W2125420735 @default.
- W1058162275 cites W2126358858 @default.
- W1058162275 cites W2127600580 @default.
- W1058162275 cites W2127685726 @default.