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- W10583791 abstract "Cytokine tumor necrosis factor-alpha (TNF-α) is recognized as an important mediator in inflammation and infection. TNF-α has recently been shown to be present also in the blood of patients with heart failure. Cachexia is not a necessary determinant for the detection of TNF-α, as it was also found in patients with severe heart failure with no evidence of weight loss. Two naturally occuring soluble receptors of TNF-α are reported to be increased in the end stage of the disease. These soluble receptors are able to modulate the TNF-α bioactivity by stabilizing or clustering the cytokine trimer. In severe heart failure short-term prognosis is unrelated to circulating TNF-α, but it is strongly correlated with the serum level of soluble TNF receptors." @default.
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- W10583791 date "1995-01-01" @default.
- W10583791 modified "2023-09-24" @default.
- W10583791 title "Tumor Necrosis Factor-Alpha in Chronic Heart Failure" @default.
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- W10583791 doi "https://doi.org/10.1007/978-1-4615-2003-0_1" @default.
- W10583791 hasPublicationYear "1995" @default.
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