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- W105890381 abstract "Coronary wave intensity (WI) reflects the effects of cardiac contraction and relaxation on coronary blood flow dynamics. The typical coronary WI pattern shows backward and forward compression waves in early systole (BCW and FCW, resp.), followed by forward and backward expansion waves (FEW and BEW, resp.) during early relaxation. The severe cardiovascular stress imposed by a Valsalva maneuver (VM) was studied in relation to coronary WI. In 8 patients undergoing cardiac catheterization, we simultaneously recorded left ventricular (LV) and aortic pressure (Pa), and intracoronary pressure (Pd) and flow velocity (v), while the patients performed a VM. WI was computed as WI = (dPd/dt)·(dv/dt). Changes in the peaks of the dominant waves were compared to changes in pulse pressure (PPa) and LV contractility (LVdPdt). During the strain phase of the VM, forward WI was reduced by almost 80% (p < 0.015). The intensity of the BEW dropped to less than half of the BCW (p < 0.02). PPa was highly correlated to the FCW and FEW (r = 0.94, p < 0.006) and LVdPdt was the major determinant of the BEW (r = 0.97, p < 0.001). We conclude that the VM strongly attenuated cardiac-coronary interaction. Reduced LV filling and contractility during the strain decreased the energy transmission from the heart to the coronary waves. The resulting decline in the early systolic FCW and early diastolic BEW served to impede coronary inflow. (Support: NHF grant 2006B186)" @default.
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- W105890381 date "2010-04-01" @default.
- W105890381 modified "2023-09-27" @default.
- W105890381 title "Effect of the Valsalva maneuver on cardiac‐coronary interaction studied by coronary wave intensity in humans" @default.
- W105890381 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1034.10" @default.
- W105890381 hasPublicationYear "2010" @default.
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