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- W1060037701 abstract "Epstein-Barr virus Latent Membrane Protein 2A (LMP2A) is expressed in EBV-infected B cells in the germinal center, a site of significant apoptosis induced by engagement of Fas on activated B cells. Signals from the B cell receptor (BCR) protect germinal center B cells from Fas-mediated apoptosis, and since LMP2A is a BCR mimic, we hypothesized that LMP2A would also protect B cells from Fas-mediated apoptosis. Surprisingly, latently-infected human and murine B cell lines expressing LMP2A were more sensitive to Fas-mediated apoptosis, as determined by increases in Annexin-V staining, and cleavage of caspase-8, -3 and PARP. Additional studies show that LMP2A-expressing B cell lines demonstrate a Lyn- and Syk-dependent increase in sensitivity to Fas-mediated apoptosis, due to an LMP2A-dependent enhancement in Fas expression. These findings demonstrate the ability for LMP2A to directly increase a pro-apoptotic molecule and have implications for EBV latency as well as the treatment of EBV-associated malignancies." @default.
- W1060037701 created "2016-06-24" @default.
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- W1060037701 date "2015-10-01" @default.
- W1060037701 modified "2023-10-10" @default.
- W1060037701 title "Epstein–Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas expression and Fas-dependent apoptosis: Role of Lyn/Syk activation" @default.
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- W1060037701 doi "https://doi.org/10.1016/j.cellimm.2015.08.001" @default.
- W1060037701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618070" @default.
- W1060037701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26255694" @default.
- W1060037701 hasPublicationYear "2015" @default.
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