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- W106063320 abstract "Publisher Summary It is well known that certain cell types mediate, or demonstrate cytotoxicity in vitro against tumor cells. Such cells are macrophages, T cytotoxic cells, K cells, NK cells. Antibody-dependent cell cytotoxicity is claimed to be the main mechanism by which K cells express their activity. This chapter describes a study to examine the ontogeny of antibody-dependent cell mediated cytotoxicity in normal and tumor bearing C3H mice. Inbred male and female C3H/He mice of 2–11 and 16 weeks of age were used. The tumor used was a syngeneic adenocarcinoma, arising spontaneously as a mammary tumor in a virgin female C3H/He mouse. The ontogeny of ADCC in normal mice using siliconized, and nonsiliconized glassware at the optimum ratio of 10:1 effector/target cells is shown. The difference observed in the ontogenic pattern after removal of a part of glass adherent cells strongly suggests the participation of such cells in ADCC activity. Results obtained after the spleen red blood cells were lysed with 0.9% ammonium chloride suggest an interfering role of such cells in ADCC." @default.
- W106063320 created "2016-06-24" @default.
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- W106063320 date "1981-01-01" @default.
- W106063320 modified "2023-09-27" @default.
- W106063320 title "ONTOGENY OF ANTIBODY-DEPENDENT CELL MEDIATED CYTOTOXICITY IN NORMAL AND TUMOR BEARING C3H MICE" @default.
- W106063320 cites W1999237928 @default.
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- W106063320 doi "https://doi.org/10.1016/b978-0-08-025922-2.50066-8" @default.
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