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- W106076265 abstract "This chapter focuses on the mechanism of anti-μ induced suppression of LPS induced immunoglobulin synthesis. In a study described in the chapter, when added to cultures of LPS-stimulated cultures of newborn or adult CBA/J spleen cells, goat anti-mouse IgM antibodies produced a dose-related suppression of B-cell maturation to plasma cells synthesizing IgM, IgG, and IgA. (Fab′)2 fragments of goat anti-μ produced equivalent suppression of IgM and IgG2 plasma cells, suggesting that phagocytosis of antibody-coated cells and antibody-dependent cell-mediated mechanisms were also not involved in suppression of differentiation. The cells induced to proliferate but blocked from further differentiation expressed Fc and C3d receptors and expressed Ia and H-2 membrane alloantigens detected by indirect immunofluorescence." @default.
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- W106076265 date "1977-01-01" @default.
- W106076265 modified "2023-09-23" @default.
- W106076265 title "MECHANISM OF ANTI-μ INDUCED SUPPRESSION OF LPS INDUCED IMMUNOGLOBULIN SYNTHESIS" @default.
- W106076265 cites W1970132368 @default.
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- W106076265 doi "https://doi.org/10.1016/b978-0-12-458050-3.50027-8" @default.
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