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- W10628985 abstract "of a dissertation at the University of Miami. Dissertation supervised by Dr. Tulay Koru-Sengul. No. of pages in text. (221) Prostate cancer is the most common solid malignancy diagnosed in American men. One in six men in the US is expected to be diagnosed with prostate cancer in his lifetime. Despite the large number of men diagnosed every year with prostate cancer, there is no consensus concerning the best and most appropriate treatment. Moreover, most men with early stage prostate cancer have a life expectancy comparable to similarly aged men without prostate cancer and will die with prostate cancer rather than from prostate cancer. Without evidence supporting one treatment over another, it is important to understand the factors that inform treatment selection and what impact they may have on survival. The Florida Cancer Data System was used to obtain data from men (n=118,533) diagnosed with prostate cancer between the years 2001 and 2009. US Census data was used to construct area-based socioeconomic measures of education and socioeconomic status. Census tract based Rural-Urban Commuting Area Codes were used to determine urban vs. rural residence. Approximately 73% of the men in this study were Non-Hispanic White, 13% Non-Hispanic Black, 11% Hispanic and 3% were categorized as Non-Hispanic Other or “Unknown” race/ethnicity. Most (81%) men were diagnosed with localized (early stage) prostate cancer. Roughly 10% of the cases were Regional/Distant (advanced stage) and 9% were not staged. Men diagnosed with localized prostate cancer received surgery (34%), radiation (32%), hormonal therapy (22%) or watchful waiting (12%) as their initial treatment. Binary logistic regression models were fitted to predict late stage prostate cancer. For men diagnosed with localized prostate cancer, polytomous logistic regression models were fitted to predict initial treatment. Lastly, survival analysis was conducted using the Kaplan-Meier method and Cox proportional hazard regression models were used to model time-to-event outcome (overall survival/all-cause mortality). The regression models were adjusted for age at diagnosis, insurance, education, marital and smoking status, SES, urban/rural residence, initial treatment and tumor grade. The results of the analyses show that sociodemographic factors were associated with stage of cancer diagnosis, initial treatment selection, and overall survival for men with prostate cancer. Non-Hispanic Black men were more likely to present with late stage disease (OR=1.16; 95% CI: 1.09, 1.23) as were men who were not married (OR=1.24; 95% CI: 1.18, 1.30) and who currently smoked (OR=1.36; 95% CI: 1.28, 1.46). Variation existed in the initial treatments for men diagnosed with localized prostate cancer. Non-Hispanic Black (OR=0.66; 95% CI: 0.61, 0.71) and Hispanic men (OR=0.85; 95% CI: 0.79, 0.92) were less likely to receive surgery or radiation therapy, respectively. Non-Hispanic Black men with the lowest socioeconomic status were less likely to receive radiation therapy over watchful waiting (OR=0.66; 95% CI: 0.50, 0.87). Compared to men with private insurance, men with no insurance were more likely to receive watchful waiting over surgery (OR=2.04; 95% CI: 1.75, 2.38), radiation therapy (OR=2.32; 95% CI: 1.96, 2.7) or hormonal therapy (OR=1.43; 95% CI: 1.22, 1.69). Men with public insurance were less likely to receive surgery (OR=0.88; 95% CI: 0.84, 0.93) and more likely to received hormonal therapy (OR=1.18; 95% CI: 1.12, 1.25) over watchful waiting. Lastly, men with less than a high school education were more likely to select watchful waiting (OR=1.11; 95% CI: 1.01, 1.2) over surgery. Cox proportional hazard regression models showed differences in overall survival based upon initial treatment and sociodemographic factors. Although surgery had better 5-year survival rates than watchful waiting (82% vs. 76%), there was no statistically significant difference in overall mortality risk between the two treatments. All of the sociodemographic predictors of interest (race/ethnicity, socioeconomic status, education level, smoking status and marital status) were significant predictors of overall mortality risk for men diagnosed with localize prostate cancer. With an eye toward reducing healthcare costs and improving efforts to eliminate health disparities, it is imperative that we understand what external factors affect screening behaviors for early detection, initial treatment selection, and survival for men diagnosed with prostate cancer." @default.
- W10628985 created "2016-06-24" @default.
- W10628985 creator A5007032669 @default.
- W10628985 creator A5019617417 @default.
- W10628985 date "2013-01-01" @default.
- W10628985 modified "2023-09-26" @default.
- W10628985 title "Sociodemographic and Clinical Factors Associated with the Diagnosis, Initial Treatment Selection and Survival of Prostate Cancer in Florida" @default.
- W10628985 cites W109707626 @default.
- W10628985 cites W1492157159 @default.
- W10628985 cites W1497311969 @default.
- W10628985 cites W1544025659 @default.
- W10628985 cites W1558007424 @default.
- W10628985 cites W1626426473 @default.
- W10628985 cites W167655454 @default.
- W10628985 cites W178338668 @default.
- W10628985 cites W180359751 @default.
- W10628985 cites W194609839 @default.
- W10628985 cites W1967543442 @default.
- W10628985 cites W1968229920 @default.
- W10628985 cites W1969314733 @default.
- W10628985 cites W1970609600 @default.
- W10628985 cites W1971204122 @default.
- W10628985 cites W1973948212 @default.
- W10628985 cites W1974801801 @default.
- W10628985 cites W1980757633 @default.
- W10628985 cites W1981115705 @default.
- W10628985 cites W1981989535 @default.
- W10628985 cites W1986879540 @default.
- W10628985 cites W1987021305 @default.
- W10628985 cites W1987633700 @default.
- W10628985 cites W1987876107 @default.
- W10628985 cites W1993122733 @default.
- W10628985 cites W1994072212 @default.
- W10628985 cites W1995185057 @default.
- W10628985 cites W1995249699 @default.
- W10628985 cites W2002395040 @default.
- W10628985 cites W2002417113 @default.
- W10628985 cites W2002930907 @default.
- W10628985 cites W2004326631 @default.
- W10628985 cites W2015270313 @default.
- W10628985 cites W2018611424 @default.
- W10628985 cites W2018994203 @default.
- W10628985 cites W2022301248 @default.
- W10628985 cites W2024275653 @default.
- W10628985 cites W2024957913 @default.
- W10628985 cites W2029483421 @default.
- W10628985 cites W2030342346 @default.
- W10628985 cites W2031048427 @default.
- W10628985 cites W2031877879 @default.
- W10628985 cites W2035022020 @default.
- W10628985 cites W2036716679 @default.
- W10628985 cites W2037205162 @default.
- W10628985 cites W2040060938 @default.
- W10628985 cites W2045873744 @default.
- W10628985 cites W2045985604 @default.
- W10628985 cites W2049915574 @default.
- W10628985 cites W2050056063 @default.
- W10628985 cites W2052196395 @default.
- W10628985 cites W2053207930 @default.
- W10628985 cites W2055533274 @default.
- W10628985 cites W2055731134 @default.
- W10628985 cites W2056183247 @default.
- W10628985 cites W2059540890 @default.
- W10628985 cites W2061414257 @default.
- W10628985 cites W2062285555 @default.
- W10628985 cites W2064859712 @default.
- W10628985 cites W2065616395 @default.
- W10628985 cites W2065989613 @default.
- W10628985 cites W2067490743 @default.
- W10628985 cites W2067692539 @default.
- W10628985 cites W2068335390 @default.
- W10628985 cites W2069567369 @default.
- W10628985 cites W2069727822 @default.
- W10628985 cites W2072031700 @default.
- W10628985 cites W2073117151 @default.
- W10628985 cites W2074581829 @default.
- W10628985 cites W2074626706 @default.
- W10628985 cites W2075280962 @default.
- W10628985 cites W2075884509 @default.
- W10628985 cites W2077778575 @default.
- W10628985 cites W2080649974 @default.
- W10628985 cites W2081240137 @default.
- W10628985 cites W2081703330 @default.
- W10628985 cites W2082467170 @default.
- W10628985 cites W2083008051 @default.
- W10628985 cites W2083386488 @default.
- W10628985 cites W2088879795 @default.
- W10628985 cites W2092154500 @default.
- W10628985 cites W2092215809 @default.
- W10628985 cites W2092682521 @default.
- W10628985 cites W2092773519 @default.
- W10628985 cites W2093792094 @default.
- W10628985 cites W2095128112 @default.
- W10628985 cites W2095919110 @default.
- W10628985 cites W2096178285 @default.
- W10628985 cites W2096526848 @default.
- W10628985 cites W2096861622 @default.
- W10628985 cites W2097676681 @default.
- W10628985 cites W2101190248 @default.
- W10628985 cites W2102917900 @default.