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• W106316614 abstract "In this study was examined the interaction between schistosomula of Schistosoma mansoni and human monocyte-derived macrophages activated with interferon gamma (IFN-gamma). Peripheral blood monocytes were matured for 6 days and activated by further culture with IFN-gamma (600 U/ml). These IFN-gamma-treated monocyte-derived macrophages are cytotoxic for the tumor cell line K562, which is not killed by nonactivated monocyte-derived macrophages. Activated monocyte-derived macrophages were incubated with schistosomula at ratios of 10(3):1 and 10(4):1 in the presence of serum pooled from patients with schistosomiasis. This antiserum promoted an increased adherence of cells to the parasite. However, the activated monocyte-derived macrophages failed to kill the schistosomula under all conditions tested. On the contrary, the monocyte-derived macrophages were killed by schistosomula in a time-dependent and antibody-dependent manner, which was most evident at a lower effector/target ratio, 200:1. Electron microscopy showed that monocyte-derived macrophages were lysed on the surface of schistosomula. Further, both monocyte-derived macrophages and contaminating blood platelets fused with the parasite surface membrane, so that the cell plasma membrane and the outer tegumental membrane formed a hybrid membrane. The results indicate that matured human monocyte-derived macrophages activated by IFN-gamma are unable to kill schistosomula. Instead, the effector cells fuse with the parasites and are lysed by them." @default.
• W106316614 created "2016-06-24" @default.
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• W106316614 date "1988-04-01" @default.
• W106316614 modified "2023-09-23" @default.
• W106316614 title "Human monocyte-derived macrophages are lysed by schistosomula of Schistosoma mansoni and fail to kill the parasite after activation with interferon gamma." @default.
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• W106316614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1880563" @default.
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