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• W10635023 abstract "Research Article1 November 1982free access A site-specific, conservative recombination system carried by bacteriophage P1. Mapping the recombinase gene cin and the cross-over sites cix for the inversion of the C segment. S. Iida S. Iida Search for more papers by this author J. Meyer J. Meyer Search for more papers by this author K.E. Kennedy K.E. Kennedy Search for more papers by this author W. Arber W. Arber Search for more papers by this author S. Iida S. Iida Search for more papers by this author J. Meyer J. Meyer Search for more papers by this author K.E. Kennedy K.E. Kennedy Search for more papers by this author W. Arber W. Arber Search for more papers by this author Author Information S. Iida, J. Meyer, K.E. Kennedy and W. Arber The EMBO Journal (1982)1:1445-1453https://doi.org/10.1002/j.1460-2075.1982.tb01336.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The bacteriophage P1 genome carries an invertible C segment consisting of 3-kb unique sequences flanked by 0.6-kb inverted repeats. With insertion and deletion mutants of P1 derivatives the site-specific recombinase gene cin for C inversion) has been mapped adjacent to the C segment and the cix sites (for C inversion cross-over) have been located at the outside ends of the inverted repeats. Inversion of the C segment functions as a biological switch and controls expression of the gene(s) responsible for phage infectivity carried on the C segment. The cin gene product can promote recombination between a ‘quasi- cix’ site on plasmid pBR322 and a cix site on P1 DNA. The junctions formed on the resulting co-integrate can also serve as cix sites. This observation implies a potential evolutionary process to bring genes under the control of a biological switch acting by DNA inversion. Previous ArticleNext Article Volume 1Issue 111 November 1982In this issue RelatedDetailsLoading ..." @default.
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• W10635023 title "A site-specific, conservative recombination system carried by bacteriophage P1. Mapping the recombinase gene cin and the cross-over sites cix for the inversion of the C segment." @default.
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• W10635023 doi "https://doi.org/10.1002/j.1460-2075.1982.tb01336.x" @default.
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