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- W106453003 abstract "The zebrafish embryotoxicity test (ZET) is considered a promising alternative model in predictive developmental toxicity testing. The basic principle of this test entails the exposure of zebrafish embryos to a test compound and the subsequent morphological assessment of developmental and teratogenic effects. To increase the sensitivity and predictability of the test by detecting subtle and more detailed responses, implementation of transcriptomics analyses may be of great value. Transcriptomics analysis provides an objective tool that enables the profound evaluation of biological processes and provides the possibility to gain insight into specific physiological, pathological, or toxicological mechanisms in a high-throughput manner. This chapter gives an overview of the current implementation of transcriptomic analysis in the zebrafish embryotoxicity test for developmental toxicity testing and discusses future perspectives for this research." @default.
- W106453003 created "2016-06-24" @default.
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- W106453003 date "2014-01-01" @default.
- W106453003 modified "2023-09-23" @default.
- W106453003 title "Implementation of Transcriptomics in the Zebrafish Embryotoxicity Test" @default.
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- W106453003 doi "https://doi.org/10.1016/b978-0-12-397862-2.00007-3" @default.
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