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• W106527851 abstract "Conventional antigen binds as a processed peptide fragment in the groove of the responder allele of the major histocompatibility complex (MHC) molecule and is recognized by the variable regions of T cell receptors (TCRs) of clonally distributed T lymphocytes (Bjorkman et al. 1987; Buus et al. 1987; Townsend et al. 1986; Davis and Bjorkman 1988; Matis 1990). An array of coreceptors (CD4, CD8, LFA-1, CD2, etc.) further strengthens the association between TCR and MHC-bound peptide antigen and provides additional signals necessary for T cell activation and triggering of T cell function (Bierer et al. 1989; Veillette et al. 1989; Staunton et al. 1989; Meuer et al. 1984b). A second category of TCR-unlinked costimulatory signals generated by antigen-presenting cells (APC) critically controls primary T cell activation (Bretscher and Cohn 1970; Geppert et al. 1990). Occupancy of the TCR and coreceptors without an APC-derived costimulus anergizes rather than activates antigen-reactive resting T cells (Jenkins et al. 1988; Schwartz 1989; Gaspari et al. 1988)." @default.
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• W106527851 date "1991-01-01" @default.
• W106527851 modified "2023-09-26" @default.
• W106527851 title "CD4/CD8 Coreceptor-Independent Costimulator-Dependent Triggering of SEB-Reactive Murine T Cells" @default.
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• W106527851 doi "https://doi.org/10.1007/978-3-642-50998-8_7" @default.
• W106527851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1802620" @default.
• W106527851 hasPublicationYear "1991" @default.
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