Matches in SemOpenAlex for { <https://semopenalex.org/work/W10656263> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W10656263 endingPage "41" @default.
- W10656263 startingPage "327" @default.
- W10656263 abstract "The antimycotic action of 1, 4-bis-(m, m'-amidinophenoxymethyl)-cyclohexane dilactate (MAC), a synthetic diamidine compound, on Candida albicans was studied. The minimum inhibitory concentration (MIC) ranged from 3.31 to 6.25 micrograms/ml against both standard and clinically isolated strains. MAC was fungistatic at MIC and weakly fungicidal at the concentration of 100 micrograms/ml. MAC did not affect the cell wall or cause cell lysis. Intracellular constituents, such as 260 nm and 280 nm absorbing materials, were released from the cells by treatment with MAC indicating that MAC affected membrane permeability. The release of 260 nm absorbing material was inhibited by the presence of Ca2+ and Mg2+. Acidic phospholipids such as cardiolipin and phosphatidylglycerol inhibited the anti-Candida activity of MAC, but sterols and lecithin were not inhibitory, indicating that MAC interacted with acidic phospholipids of the cell membrane. Freeze-fracture electron microscopy showed that MAC caused aggregation of membrane particles and patch formation on the P face, which may indicate that MAC is a membrane disrupting agent. It appeared that MAC affected C. albicans at the cell membrane by interacting with acidic phospholipids and caused disorganization of the membrane structure resulting in the release of intracellular constituents without lysis." @default.
- W10656263 created "2016-06-24" @default.
- W10656263 creator A5091900691 @default.
- W10656263 date "1981-11-01" @default.
- W10656263 modified "2023-09-23" @default.
- W10656263 title "Antimycotic action of a diamidine compound, 1, 4-bis-(m, m'-amidinophenoxymethyl)-cyclohexane dilactate, on Candida albicans." @default.
- W10656263 doi "https://doi.org/10.18926/amo/31277" @default.
- W10656263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6458996" @default.
- W10656263 hasPublicationYear "1981" @default.
- W10656263 type Work @default.
- W10656263 sameAs 10656263 @default.
- W10656263 citedByCount "0" @default.
- W10656263 crossrefType "journal-article" @default.
- W10656263 hasAuthorship W10656263A5091900691 @default.
- W10656263 hasConcept C176947019 @default.
- W10656263 hasConcept C185592680 @default.
- W10656263 hasConcept C202751555 @default.
- W10656263 hasConcept C2776120743 @default.
- W10656263 hasConcept C2776330855 @default.
- W10656263 hasConcept C2778106830 @default.
- W10656263 hasConcept C2778918659 @default.
- W10656263 hasConcept C2779934242 @default.
- W10656263 hasConcept C2780726299 @default.
- W10656263 hasConcept C2780917455 @default.
- W10656263 hasConcept C41625074 @default.
- W10656263 hasConcept C55493867 @default.
- W10656263 hasConcept C57409179 @default.
- W10656263 hasConcept C79879829 @default.
- W10656263 hasConcept C86803240 @default.
- W10656263 hasConcept C89423630 @default.
- W10656263 hasConceptScore W10656263C176947019 @default.
- W10656263 hasConceptScore W10656263C185592680 @default.
- W10656263 hasConceptScore W10656263C202751555 @default.
- W10656263 hasConceptScore W10656263C2776120743 @default.
- W10656263 hasConceptScore W10656263C2776330855 @default.
- W10656263 hasConceptScore W10656263C2778106830 @default.
- W10656263 hasConceptScore W10656263C2778918659 @default.
- W10656263 hasConceptScore W10656263C2779934242 @default.
- W10656263 hasConceptScore W10656263C2780726299 @default.
- W10656263 hasConceptScore W10656263C2780917455 @default.
- W10656263 hasConceptScore W10656263C41625074 @default.
- W10656263 hasConceptScore W10656263C55493867 @default.
- W10656263 hasConceptScore W10656263C57409179 @default.
- W10656263 hasConceptScore W10656263C79879829 @default.
- W10656263 hasConceptScore W10656263C86803240 @default.
- W10656263 hasConceptScore W10656263C89423630 @default.
- W10656263 hasIssue "5" @default.
- W10656263 hasLocation W106562631 @default.
- W10656263 hasOpenAccess W10656263 @default.
- W10656263 hasPrimaryLocation W106562631 @default.
- W10656263 hasRelatedWork W10656263 @default.
- W10656263 hasRelatedWork W1994510236 @default.
- W10656263 hasRelatedWork W2033793466 @default.
- W10656263 hasRelatedWork W2063052719 @default.
- W10656263 hasRelatedWork W2119554131 @default.
- W10656263 hasRelatedWork W2166430125 @default.
- W10656263 hasRelatedWork W2476310520 @default.
- W10656263 hasRelatedWork W2482787946 @default.
- W10656263 hasRelatedWork W3111991207 @default.
- W10656263 hasRelatedWork W4200477867 @default.
- W10656263 hasVolume "35" @default.
- W10656263 isParatext "false" @default.
- W10656263 isRetracted "false" @default.
- W10656263 magId "10656263" @default.
- W10656263 workType "article" @default.