Matches in SemOpenAlex for { <https://semopenalex.org/work/W10657539> ?p ?o ?g. }
- W10657539 endingPage "245" @default.
- W10657539 startingPage "235" @default.
- W10657539 abstract "Pre-messenger RNA splicing is significantly changed in cancer cells leading to the expression of cancer-specific transcripts. These transcripts have the potential to be used as cancer biomarkers and also as targets for new therapeutic approaches. In addition, the cancer-specific transcripts have the potential to alter the drug response of the cancer cells creating a chemo-resistant state. This later property of alternative splicing presents a challenge to clinicians in the design of effective therapeutic regimens. When a patient's cancer relapses it is frequently refractory to standard chemotherapies resulting in a poor clinical outcome. Therefore, understanding the mechanisms of how alternative splicing can lead to chemo-resistance is critical to the effective delivery of treatment. Here, we will discuss the impact of alternative splicing variants on drug metabolism and activation; on drug interactions with cell signaling pathways; and on cell death pathways in cancer therapeutics. In addition to the initial characterization of splicing variants, the mechanisms leading to alterations in splicing are being studied in the setting of chemo-resistance and will be discussed here. The promise of therapeutic intervention to obviate the impact of these splicing variants will significantly enhance treatment options for cancer patients." @default.
- W10657539 created "2016-06-24" @default.
- W10657539 creator A5001354914 @default.
- W10657539 creator A5019127443 @default.
- W10657539 creator A5079663967 @default.
- W10657539 date "2013-01-01" @default.
- W10657539 modified "2023-10-13" @default.
- W10657539 title "Clinical Perspective on Chemo-Resistance and the Role of RNA Processing" @default.
- W10657539 cites W1964767165 @default.
- W10657539 cites W1970854919 @default.
- W10657539 cites W1995048208 @default.
- W10657539 cites W2002369761 @default.
- W10657539 cites W2011845259 @default.
- W10657539 cites W2012151258 @default.
- W10657539 cites W2030481178 @default.
- W10657539 cites W2036224413 @default.
- W10657539 cites W2040870350 @default.
- W10657539 cites W2045232151 @default.
- W10657539 cites W2054106515 @default.
- W10657539 cites W2055251173 @default.
- W10657539 cites W2057740429 @default.
- W10657539 cites W2073683821 @default.
- W10657539 cites W2082491111 @default.
- W10657539 cites W2089465951 @default.
- W10657539 cites W2096674266 @default.
- W10657539 cites W2102838147 @default.
- W10657539 cites W2102878612 @default.
- W10657539 cites W2108653941 @default.
- W10657539 cites W2109178352 @default.
- W10657539 cites W2123558100 @default.
- W10657539 cites W2127892722 @default.
- W10657539 cites W2128012941 @default.
- W10657539 cites W2133279561 @default.
- W10657539 cites W2142751465 @default.
- W10657539 cites W2153052534 @default.
- W10657539 cites W2159946903 @default.
- W10657539 cites W2161018138 @default.
- W10657539 cites W2167323964 @default.
- W10657539 cites W2170343590 @default.
- W10657539 cites W2244390199 @default.
- W10657539 cites W26577954 @default.
- W10657539 cites W41336079 @default.
- W10657539 cites W4244140331 @default.
- W10657539 cites W4323873844 @default.
- W10657539 doi "https://doi.org/10.1007/978-3-642-31659-3_10" @default.
- W10657539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24222361" @default.
- W10657539 hasPublicationYear "2013" @default.
- W10657539 type Work @default.
- W10657539 sameAs 10657539 @default.
- W10657539 citedByCount "3" @default.
- W10657539 countsByYear W106575392015 @default.
- W10657539 countsByYear W106575392016 @default.
- W10657539 countsByYear W106575392020 @default.
- W10657539 crossrefType "book-chapter" @default.
- W10657539 hasAuthorship W10657539A5001354914 @default.
- W10657539 hasAuthorship W10657539A5019127443 @default.
- W10657539 hasAuthorship W10657539A5079663967 @default.
- W10657539 hasConcept C104317684 @default.
- W10657539 hasConcept C105580179 @default.
- W10657539 hasConcept C114851261 @default.
- W10657539 hasConcept C121608353 @default.
- W10657539 hasConcept C126322002 @default.
- W10657539 hasConcept C194583182 @default.
- W10657539 hasConcept C502942594 @default.
- W10657539 hasConcept C54355233 @default.
- W10657539 hasConcept C54458228 @default.
- W10657539 hasConcept C60644358 @default.
- W10657539 hasConcept C67705224 @default.
- W10657539 hasConcept C71924100 @default.
- W10657539 hasConcept C86803240 @default.
- W10657539 hasConcept C96232424 @default.
- W10657539 hasConceptScore W10657539C104317684 @default.
- W10657539 hasConceptScore W10657539C105580179 @default.
- W10657539 hasConceptScore W10657539C114851261 @default.
- W10657539 hasConceptScore W10657539C121608353 @default.
- W10657539 hasConceptScore W10657539C126322002 @default.
- W10657539 hasConceptScore W10657539C194583182 @default.
- W10657539 hasConceptScore W10657539C502942594 @default.
- W10657539 hasConceptScore W10657539C54355233 @default.
- W10657539 hasConceptScore W10657539C54458228 @default.
- W10657539 hasConceptScore W10657539C60644358 @default.
- W10657539 hasConceptScore W10657539C67705224 @default.
- W10657539 hasConceptScore W10657539C71924100 @default.
- W10657539 hasConceptScore W10657539C86803240 @default.
- W10657539 hasConceptScore W10657539C96232424 @default.
- W10657539 hasLocation W106575391 @default.
- W10657539 hasLocation W106575392 @default.
- W10657539 hasOpenAccess W10657539 @default.
- W10657539 hasPrimaryLocation W106575391 @default.
- W10657539 hasRelatedWork W2023199111 @default.
- W10657539 hasRelatedWork W2052498125 @default.
- W10657539 hasRelatedWork W2065030615 @default.
- W10657539 hasRelatedWork W2094867951 @default.
- W10657539 hasRelatedWork W2321791250 @default.
- W10657539 hasRelatedWork W2426516634 @default.
- W10657539 hasRelatedWork W2564462691 @default.
- W10657539 hasRelatedWork W2885403345 @default.
- W10657539 hasRelatedWork W4213427798 @default.