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- W106691645 abstract "Acetylcholine, the main neurotransmitter of the parasympathetic nervous system, acts by binding to two major receptor types, the nicotinic and the muscarinic receptor classes. Muscarinic receptors are composed of five subtypes, M1—M5, encoded by intronless genes, with endogenously expressed correlates in several tissues, including the respiratory tract []. Given this diversity, it has been a challenge to define the physiological roles for each subtype. As discussed below, a paucity of selective ligands remains for use as defining pharmacological tools, but gene-targeting techniques, such as receptor antisense and transgenic animals, could assist in this respect. While the antisense techniques have not met with much success in the examination of smooth muscle function, it is fair to state that this has not been exten-sively studied. Alternatively, transgenic mice, lacking muscarinic M1, M2, M4 or M5 receptor genes, have now been constructed but, as yet, no studies have been reported relating to airway smooth muscle function." @default.
- W106691645 created "2016-06-24" @default.
- W106691645 creator A5044236614 @default.
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- W106691645 date "2001-01-01" @default.
- W106691645 modified "2023-10-14" @default.
- W106691645 title "Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle" @default.
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- W106691645 doi "https://doi.org/10.1007/978-3-0348-8358-0_4" @default.
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