Matches in SemOpenAlex for { <https://semopenalex.org/work/W106703563> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W106703563 abstract "Publisher Summary This chapter describes three monoclonal antibodies—DA6 231, 164, and 147— that precipitate glycoprotein dimers consisting of 34 K and 29 K subunits. 231 and 147 recognize DR-common epitopes, whereas 164 binds to all except DR7 homozygous cell lines. Protein transfer from sodium dodecyl sulfate (SDS) polyacrylamide gels to nitrocellulose paper, followed by probing with the monoclonal antibodies, has permitted assignment of the 231 and 147 epitopes to 29 K and 34 K subunits, respectively. Mutual binding inhibition between 231 and 164 is incomplete in one direction, suggesting that there is a major proportion of 231 + 164 + and a minority of 231 + 164 – 29K molecules expressed on all DR positive cells tested, except DR7 homozygous cells that have lost the 164 epitope. The serological expression of the 147 epitope at the cell surface is complex. The 231/147 ratio on peripheral and activated β lymphocytes is much higher than on β lymphoblastoid lines or on chronic lymphocytic leukemia cells. No significant binding of 147 can be detected on the strongly 231 + 164 + -activated cultured τ cells. Preliminary evidence suggests that molecules that can bind 147 are released on cell lysis even from 147 – activated τ cells." @default.
- W106703563 created "2016-06-24" @default.
- W106703563 creator A5016057209 @default.
- W106703563 creator A5033703140 @default.
- W106703563 creator A5053249043 @default.
- W106703563 creator A5058474107 @default.
- W106703563 creator A5090484036 @default.
- W106703563 date "1982-01-01" @default.
- W106703563 modified "2023-09-26" @default.
- W106703563 title "TOWARD ANALYSIS OF THE HLA-DR SYSTEM WITH MONOCLONAL ANTIBODIES" @default.
- W106703563 doi "https://doi.org/10.1016/b978-0-12-045560-7.50098-6" @default.
- W106703563 hasPublicationYear "1982" @default.
- W106703563 type Work @default.
- W106703563 sameAs 106703563 @default.
- W106703563 citedByCount "0" @default.
- W106703563 crossrefType "book-chapter" @default.
- W106703563 hasAuthorship W106703563A5016057209 @default.
- W106703563 hasAuthorship W106703563A5033703140 @default.
- W106703563 hasAuthorship W106703563A5053249043 @default.
- W106703563 hasAuthorship W106703563A5058474107 @default.
- W106703563 hasAuthorship W106703563A5090484036 @default.
- W106703563 hasConcept C108625454 @default.
- W106703563 hasConcept C153911025 @default.
- W106703563 hasConcept C159654299 @default.
- W106703563 hasConcept C163864487 @default.
- W106703563 hasConcept C185592680 @default.
- W106703563 hasConcept C195616568 @default.
- W106703563 hasConcept C203014093 @default.
- W106703563 hasConcept C542903549 @default.
- W106703563 hasConcept C54355233 @default.
- W106703563 hasConcept C81885089 @default.
- W106703563 hasConcept C86803240 @default.
- W106703563 hasConceptScore W106703563C108625454 @default.
- W106703563 hasConceptScore W106703563C153911025 @default.
- W106703563 hasConceptScore W106703563C159654299 @default.
- W106703563 hasConceptScore W106703563C163864487 @default.
- W106703563 hasConceptScore W106703563C185592680 @default.
- W106703563 hasConceptScore W106703563C195616568 @default.
- W106703563 hasConceptScore W106703563C203014093 @default.
- W106703563 hasConceptScore W106703563C542903549 @default.
- W106703563 hasConceptScore W106703563C54355233 @default.
- W106703563 hasConceptScore W106703563C81885089 @default.
- W106703563 hasConceptScore W106703563C86803240 @default.
- W106703563 hasLocation W1067035631 @default.
- W106703563 hasOpenAccess W106703563 @default.
- W106703563 hasPrimaryLocation W1067035631 @default.
- W106703563 hasRelatedWork W1484685141 @default.
- W106703563 hasRelatedWork W148765765 @default.
- W106703563 hasRelatedWork W1495236732 @default.
- W106703563 hasRelatedWork W1534537742 @default.
- W106703563 hasRelatedWork W1554142439 @default.
- W106703563 hasRelatedWork W1561903001 @default.
- W106703563 hasRelatedWork W1664112592 @default.
- W106703563 hasRelatedWork W1973605803 @default.
- W106703563 hasRelatedWork W2000409284 @default.
- W106703563 hasRelatedWork W2022675272 @default.
- W106703563 hasRelatedWork W2027580030 @default.
- W106703563 hasRelatedWork W2038449299 @default.
- W106703563 hasRelatedWork W2045854985 @default.
- W106703563 hasRelatedWork W2058137796 @default.
- W106703563 hasRelatedWork W2093902503 @default.
- W106703563 hasRelatedWork W2094280450 @default.
- W106703563 hasRelatedWork W2095085647 @default.
- W106703563 hasRelatedWork W2148795118 @default.
- W106703563 hasRelatedWork W2467243810 @default.
- W106703563 hasRelatedWork W291720588 @default.
- W106703563 isParatext "false" @default.
- W106703563 isRetracted "false" @default.
- W106703563 magId "106703563" @default.
- W106703563 workType "book-chapter" @default.