Matches in SemOpenAlex for { <https://semopenalex.org/work/W1067180544> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1067180544 endingPage "181" @default.
- W1067180544 startingPage "174" @default.
- W1067180544 abstract "Azilsartan medoxomil potassium salt (TAK-491) is an orally administered angiotensin II type 1 receptor blocker for the treatment of hypertension and is an ester-based prodrug that is rapidly hydrolyzed to the pharmacologically active moiety, azilsartan (TAK-536), during absorption. TAK-536 is biotransformed to the 2 metabolites M-I by decarboxylation and M-II by dealkylation. In this study, we developed and validated a LC/MS/MS method which can simultaneously determine 4 analytes, TAK-491, TAK-536, M-I and M-II. The bioanalytical method can be outlined as follows: two structural analogues are used as the internal standards. The analytes and the IS are extracted from human plasma using solid phase extraction. After evaporating, the residue is reconstituted and injected into a LC/MS/MS system with an ESI probe and analyzed in the positive ion mode. Separation is performed through a conventional reversed-phase column with a mobile phase of water/acetonitrile/acetic acid (40:60:0.05, v/v/v) mixture at a flow rate of 0.2 mL/min. The total run time is 8.5 min. The calibration range is 1–2500 ng/mL in human plasma for all the analytes. Instability issues of the prodrug, TAK-491, were overcome and all the validation results met the acceptance criteria in accordance with the regulatory guideline/guidance. As a result of the clinical study, the human PK profiles of TAK-536, M-I and M-II were successfully obtained and also it was confirmed that TAK-491 was below the LLOQ (1 ng/mL) in the human plasma samples." @default.
- W1067180544 created "2016-06-24" @default.
- W1067180544 creator A5062936150 @default.
- W1067180544 creator A5068588909 @default.
- W1067180544 creator A5072673296 @default.
- W1067180544 creator A5074749615 @default.
- W1067180544 creator A5091858799 @default.
- W1067180544 date "2015-09-01" @default.
- W1067180544 modified "2023-09-23" @default.
- W1067180544 title "Development, validation and application of the liquid chromatography tandem mass spectrometry method for simultaneous quantification of azilsartan medoxomil (TAK-491), azilsartan (TAK-536), and its 2 metabolites in human plasma" @default.
- W1067180544 cites W1975894373 @default.
- W1067180544 cites W1989618907 @default.
- W1067180544 cites W1990495497 @default.
- W1067180544 cites W1999260259 @default.
- W1067180544 cites W2003490733 @default.
- W1067180544 cites W2009023576 @default.
- W1067180544 cites W2052170329 @default.
- W1067180544 cites W2055340962 @default.
- W1067180544 cites W2058552757 @default.
- W1067180544 cites W2059142487 @default.
- W1067180544 cites W2064292547 @default.
- W1067180544 cites W2073682495 @default.
- W1067180544 cites W2077824951 @default.
- W1067180544 cites W2087374849 @default.
- W1067180544 cites W2114847078 @default.
- W1067180544 cites W2163635092 @default.
- W1067180544 cites W4254657679 @default.
- W1067180544 doi "https://doi.org/10.1016/j.jchromb.2015.07.047" @default.
- W1067180544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26279009" @default.
- W1067180544 hasPublicationYear "2015" @default.
- W1067180544 type Work @default.
- W1067180544 sameAs 1067180544 @default.
- W1067180544 citedByCount "6" @default.
- W1067180544 countsByYear W10671805442016 @default.
- W1067180544 countsByYear W10671805442017 @default.
- W1067180544 countsByYear W10671805442018 @default.
- W1067180544 countsByYear W10671805442020 @default.
- W1067180544 countsByYear W10671805442021 @default.
- W1067180544 crossrefType "journal-article" @default.
- W1067180544 hasAuthorship W1067180544A5062936150 @default.
- W1067180544 hasAuthorship W1067180544A5068588909 @default.
- W1067180544 hasAuthorship W1067180544A5072673296 @default.
- W1067180544 hasAuthorship W1067180544A5074749615 @default.
- W1067180544 hasAuthorship W1067180544A5091858799 @default.
- W1067180544 hasConcept C10390740 @default.
- W1067180544 hasConcept C108215921 @default.
- W1067180544 hasConcept C112705442 @default.
- W1067180544 hasConcept C137535248 @default.
- W1067180544 hasConcept C162356407 @default.
- W1067180544 hasConcept C185592680 @default.
- W1067180544 hasConcept C31827203 @default.
- W1067180544 hasConcept C43617362 @default.
- W1067180544 hasConcept C55493867 @default.
- W1067180544 hasConcept C71043704 @default.
- W1067180544 hasConcept C71924100 @default.
- W1067180544 hasConcept C81426234 @default.
- W1067180544 hasConcept C98274493 @default.
- W1067180544 hasConceptScore W1067180544C10390740 @default.
- W1067180544 hasConceptScore W1067180544C108215921 @default.
- W1067180544 hasConceptScore W1067180544C112705442 @default.
- W1067180544 hasConceptScore W1067180544C137535248 @default.
- W1067180544 hasConceptScore W1067180544C162356407 @default.
- W1067180544 hasConceptScore W1067180544C185592680 @default.
- W1067180544 hasConceptScore W1067180544C31827203 @default.
- W1067180544 hasConceptScore W1067180544C43617362 @default.
- W1067180544 hasConceptScore W1067180544C55493867 @default.
- W1067180544 hasConceptScore W1067180544C71043704 @default.
- W1067180544 hasConceptScore W1067180544C71924100 @default.
- W1067180544 hasConceptScore W1067180544C81426234 @default.
- W1067180544 hasConceptScore W1067180544C98274493 @default.
- W1067180544 hasLocation W10671805441 @default.
- W1067180544 hasLocation W10671805442 @default.
- W1067180544 hasOpenAccess W1067180544 @default.
- W1067180544 hasPrimaryLocation W10671805441 @default.
- W1067180544 hasRelatedWork W1964710877 @default.
- W1067180544 hasRelatedWork W2004208954 @default.
- W1067180544 hasRelatedWork W2008161654 @default.
- W1067180544 hasRelatedWork W2058346847 @default.
- W1067180544 hasRelatedWork W2062280554 @default.
- W1067180544 hasRelatedWork W2117645760 @default.
- W1067180544 hasRelatedWork W2169361849 @default.
- W1067180544 hasRelatedWork W3023432142 @default.
- W1067180544 hasRelatedWork W3028635380 @default.
- W1067180544 hasRelatedWork W3134784103 @default.
- W1067180544 hasVolume "1001" @default.
- W1067180544 isParatext "false" @default.
- W1067180544 isRetracted "false" @default.
- W1067180544 magId "1067180544" @default.
- W1067180544 workType "article" @default.