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- W106854518 abstract "Specific treatment of the metastatic gastric cancer is based on systemic chemotherapy. Among numerous schedules, polychemotherapies based on 5-FU and cisplatin (± anthracyclin), as CF and ECF, remain international standards. Over the ten last years, new cytotoxics proved to be efficient as taxanes, oxaliplatine, oral 5-FU (capecitabine) and irinotecan. New schedules of chemotherapy were validated, allowing either a (moderate) benefit in survival or an equivalent survival with better tolerance. Anyway median survival remains inferior to 12 months. Targeted therapies are promising. Today, only anti-HER2 therapy (traztuzumab in association with 5-FU and cisplatin), limited to gastric cancer overexpressing HER2 (20% of cases), is validated in clinical practice. Phase III studies testing anti-EGFR, and at less extent anti-VEGF, failed to deliver satisfactory results. Nonetheless, numerous studies are ongoing and could be promising, for instance regarding anti-cMet therapies. Finally, fewstudies have investigated global therapeutic strategies. But the efficiency of a 2nd line chemotherapy (with irinotecan or taxane) is now well established by phase III studies." @default.
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- W106854518 date "2013-03-01" @default.
- W106854518 modified "2023-09-25" @default.
- W106854518 title "Cancer de l’estomac métastatique : traitement médical" @default.
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- W106854518 doi "https://doi.org/10.1007/s10269-013-2268-8" @default.
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