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- W106892272 abstract "The vitamin, 24R,24,25-dihydroxyvitamin D/sub 3/, is capable of inducing a minimal intestinal calcium transport response in chicks when compared to an equal amount of 25-hydroxyvitamin D/sub 3/. 1,24,25-Trihydroxyvitamin D/sub 3/ is also less active than 1,25-dihydroxyvitamin D/sub 3/, and its activity is much shorter lived than that of 1,25-dihydroxyvitamin D/sub 3/. A comparison of the metabolism of 25-hydroxy(26,27-/sup 3/H)vitamin D/sub 3/ and 24,25-dihydroxy(26,27-/sup 3/H)vitamin D/sub 3/ in the rat and chick shows that 24,25-dihydroxyvitamin D/sub 3/ and 1,24,25-trihydroxyvitamin D/sub 3/ disappear at least 10 times more rapidly from the blood and intestine of chicks. Furthermore, examination of the excretory products from both of these species demonstrates that chicks receiving a single dose of 24,25-dihydroxy(26,27-/sup 3/H)vitamin D/sub 3/ excrete 66% of the total radioactivity by 48 hours, whereas rats receiving the same dose excrete less than one-half that amount. These results demonstrate that 24,25-dihydroxyvitamin D/sub 3/ is considerably less biologically active in the chick than in the rat, probably due to more rapid metabolism and excretion." @default.
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- W106892272 date "1976-01-25" @default.
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- W106892272 title "Metabolism and biological activity of 24,25-dihydroxyvitamin D/sub 3/ in the chick" @default.
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