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• W106965076 abstract "Transforming growth factor-β (TGF-β) is a member of a superfamily of cytokines involved in many biological processes in both normal and cancer cells. The effects of TGF-β include the regulation of growth and proliferation, the migration and invasiveness of cells as well as cell survival and death. Beside these TGF-β effects in adult mammalian organisms, TGF-β is involved in the specification of cell fate during embryogenesis. Deregulation of the TGF-β-signaling cascade is a common process in many diseases, notably cancer. Although TGF-β may acts as a tumor suppressor in the early pathogenesis of some cancers such as colon cancer, it becomes a malignancy-associated cytokine during tumor progression both because of autocrine and paracrine, mostly immunosuppressive effects. Blocking the TGF-β-signaling pathway is therefore a promising approach of cancer therapy. Preclinical studies of blocking TGF-β signaling in tumor or immune cells by expressing soluble TGF-β receptors or by inhibiting the intracellular TGF-β signaling cascade via blocking the kinase activity of the ligand/receptor complex have shown promise in a variety of different tumor models. In contrast to soluble TGF-β receptors, dominant-negative, kinase-dead versions of TGF-β receptors (dnR) show ambilateral effects. While dnR might block autocrine TGF-β effects such as tumor cell motility in cancer cells, dnR expression in normal lymphocytes or breast cells may also lead to a more aggressive tumor growth by indirect or direct mechanisms, respectively. Altogether these observations from animal models demonstrate both the potential value and the risks of targeting TGF-β as a therapeutic approach to cancer. At present, small molecules blocking the intracellular TGF-β signaling cascade are probably the most promising therapeutics in the treatment of cancers which depend on enhanced TGF-β activity." @default.
• W106965076 created "2016-06-24" @default.
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• W106965076 date "2008-01-01" @default.
• W106965076 modified "2023-09-27" @default.
• W106965076 title "Modulating TGF-β Receptor Signaling: A Novel Approach of Cancer Therapy" @default.
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• W106965076 doi "https://doi.org/10.1007/978-1-59745-293-9_39" @default.
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