Matches in SemOpenAlex for { <https://semopenalex.org/work/W1070036> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1070036 endingPage "52" @default.
- W1070036 startingPage "41" @default.
- W1070036 abstract "Biopharmaceuticals generally describe drugs synthesized by biotechnology rather than chemistry, and are normally macromolecules such as proteins (vaccines, antibodies, hormones) or nucleic acids (RNA, DNA), but could also include synthetic biology ambitions such as designed therapeutic microorganisms. AstaZeneca has an experimental protein crystallography research group at each of its three research sites (Sweden, USA and UK). These groups support small molecule drug design for local projects as their main focus. AstraZeneca acquired MedImmune in 2007 as a strategic boost of its biopharmaceutical capability. Currently, there is no experimental structure capability within MedImmune. A question arose whether the current structural support facility could address MedImmune projects with business impact. This chapter illustrates two cases where structural support provided unique information that could be incorporated into the patenting strategy in a timely fashion. These are structures of antibody-antigen complexes, which provide definitive epitope characterization. The structure of two interleukins, IL-17A and IL-15 are presented in complex with neutralizing antibodies that have been subjected to in-vitro affinity maturation. For the IL-17A antibody, the affinity maturation optimization process resulted in seven amino changes increasing affinity 6-fold and activity 30-fold. For the IL-15 antibody, there were nine amino acid changes with affinity increasing 228-fold and activity increasing a staggering 40,000-fold. We were intrigued to see whether the structures would help explain this, as well as providing the definitive epitopes." @default.
- W1070036 created "2016-06-24" @default.
- W1070036 creator A5077364403 @default.
- W1070036 date "2015-01-01" @default.
- W1070036 modified "2023-09-25" @default.
- W1070036 title "Crystallography and Biopharmaceuticals" @default.
- W1070036 cites W1567604499 @default.
- W1070036 cites W1576522185 @default.
- W1070036 cites W1911161962 @default.
- W1070036 cites W1970563382 @default.
- W1070036 cites W1977283614 @default.
- W1070036 cites W1981274089 @default.
- W1070036 cites W1987628377 @default.
- W1070036 cites W1994342014 @default.
- W1070036 cites W2006174330 @default.
- W1070036 cites W2006249161 @default.
- W1070036 cites W2009438958 @default.
- W1070036 cites W2014785961 @default.
- W1070036 cites W2022378336 @default.
- W1070036 cites W2027854096 @default.
- W1070036 cites W2032299291 @default.
- W1070036 cites W2032812303 @default.
- W1070036 cites W2043904728 @default.
- W1070036 cites W2057623222 @default.
- W1070036 cites W2073266561 @default.
- W1070036 cites W2073313785 @default.
- W1070036 cites W2112006696 @default.
- W1070036 cites W2114747432 @default.
- W1070036 cites W2115631255 @default.
- W1070036 cites W2119080021 @default.
- W1070036 cites W2126874760 @default.
- W1070036 cites W2136357996 @default.
- W1070036 cites W2139056292 @default.
- W1070036 cites W2144081223 @default.
- W1070036 cites W2171690009 @default.
- W1070036 doi "https://doi.org/10.1007/978-94-017-9719-1_4" @default.
- W1070036 hasPublicationYear "2015" @default.
- W1070036 type Work @default.
- W1070036 sameAs 1070036 @default.
- W1070036 citedByCount "0" @default.
- W1070036 crossrefType "book-chapter" @default.
- W1070036 hasAuthorship W1070036A5077364403 @default.
- W1070036 hasConcept C147483822 @default.
- W1070036 hasConcept C150903083 @default.
- W1070036 hasConcept C159654299 @default.
- W1070036 hasConcept C185592680 @default.
- W1070036 hasConcept C195616568 @default.
- W1070036 hasConcept C203014093 @default.
- W1070036 hasConcept C2781047461 @default.
- W1070036 hasConcept C55493867 @default.
- W1070036 hasConcept C70721500 @default.
- W1070036 hasConcept C86803240 @default.
- W1070036 hasConceptScore W1070036C147483822 @default.
- W1070036 hasConceptScore W1070036C150903083 @default.
- W1070036 hasConceptScore W1070036C159654299 @default.
- W1070036 hasConceptScore W1070036C185592680 @default.
- W1070036 hasConceptScore W1070036C195616568 @default.
- W1070036 hasConceptScore W1070036C203014093 @default.
- W1070036 hasConceptScore W1070036C2781047461 @default.
- W1070036 hasConceptScore W1070036C55493867 @default.
- W1070036 hasConceptScore W1070036C70721500 @default.
- W1070036 hasConceptScore W1070036C86803240 @default.
- W1070036 hasLocation W10700361 @default.
- W1070036 hasOpenAccess W1070036 @default.
- W1070036 hasPrimaryLocation W10700361 @default.
- W1070036 hasRelatedWork W1604248381 @default.
- W1070036 hasRelatedWork W1872459230 @default.
- W1070036 hasRelatedWork W1922768394 @default.
- W1070036 hasRelatedWork W2072064937 @default.
- W1070036 hasRelatedWork W2072651352 @default.
- W1070036 hasRelatedWork W2091572326 @default.
- W1070036 hasRelatedWork W2095965685 @default.
- W1070036 hasRelatedWork W2313745184 @default.
- W1070036 hasRelatedWork W4244618944 @default.
- W1070036 hasRelatedWork W4250805943 @default.
- W1070036 isParatext "false" @default.
- W1070036 isRetracted "false" @default.
- W1070036 magId "1070036" @default.
- W1070036 workType "book-chapter" @default.