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- W10711965 abstract "Purpose To investigate oral precancerous lesions and head and neck squamous cell carcinoma in a rat model through Micro PET/CT imaging. Material and Methods 39 immunocompetent male SD (Sprague Dawley) rats were used for the study. They were divided into two groups. 33 of them drank a 0.002% 4-nitroquinoline-1-oxide (4NQO) solution during the first 13 weeks, and thereafter normal water. The other 6 rats drank normal water at all times. During 25th to 30th weeks of the experiment, 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET/CT was performed for these rats. The maximum standardized uptake value (SUVmax) and T/NT ratios were measured. One day after the imaging, rats were euthanized and pathological features were assessed by the hematoxylin-eosin (HE) staining. Results The pathologic grade of the lesions increased with time in rats that were fed 4NQO solution, from normal tissue, precancerous lesions to cancerous tissue. No histological changes were seen in the rats who drank normal water. There was no significant difference in SUVmax among the normal group, precancerous group and cancerous group ( p > 0.05). There was significant difference in T/NT (muscle, brain) between the normal group and the cancerous group ( p p > 0.05); and no significant difference between the precancerous group and the cancerous group ( p > 0.05). The T/NT (muscle, brain) ratios increased along with the increase of the pathologic grade of the lesions. There was no significant difference in T/NT (thyroid) among the three groups and no correlation between the T/NT (thyroid) ratios and the pathologic grade. Conclusions Micro PET/CT is a non-invasive technology that may contribute to dynamic studies of the process of carcinogenesis. T/NT (muscle, brain) ratios could, to some extent, show the degree of carcinogenesis of lesions of rats’ tongue." @default.
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- W10711965 date "2013-05-01" @default.
- W10711965 modified "2023-09-27" @default.
- W10711965 title "PP032" @default.
- W10711965 doi "https://doi.org/10.1016/j.oraloncology.2013.03.275" @default.
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