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- W107198323 abstract "Objective To investigate the clinical significance of differences of glomerular filtration rate (GFR) and creatine clearance rate (Ccr)in differential diagnosis of patients with acute renal failure (ARF)and chronic renal failure (CRF). Methods First,63 Patients in Department of Nephrology,Hainan Province People's Hospital,were enrolled in present study and 33 definitely diagnosised as ARF cases and 30 CRF cases,59 patients were undergone renal-biopsy and the other 4 patients with CRF were not. Self-controlled study was adopted in this study. The level of GFR was determined by radionuclide renal dynamic imaging with 99mTc -DTPA,serum levels of Scr was assayed by an automatic biochemical analyzer and Ccr was calculated by the formula Cockcroft-Gault,compared the GFR-Ccr difference value in the patients with ARF and CRF. Second,the patients with ARF were consecutively divided into ARF with glomerulus damage (ARF-G)and ARF with renal tubular damage (ARF-T),and the detective index was same as above. Results There were no significant difference in Scr and GFR between the patients with ARF and CRF (P0.05),while the level of GFR-Ccr was increased (18.8±13.97ml/min)in the patients with ARF,as compared to the patients with CRF(10.78±12.46ml/min)(P0.05).There were no significant differences in the levels of Scr and GFR among the patients with ARF-T,ARF-G and CRF (P0.05,all ),but the level of GFR-Cc(r25.09±13.46ml/min)was higher than those with ARF-G or CRF(13.56±12.41 and 10.78±12.46 ml/min,respectively. P0.05,all); No statistical significance was found in level of GFR-Ccr between the patients with ARF- G and CRF (P0.05). Conclusions The difference of level of GFR-Ccr is helpful for differential diagnosis of AFR and CRF patients,and the difference of level of GFR-Ccr of over 25 ml/min may suggest the ARF with renal tubular damage." @default.
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- W107198323 date "2009-01-01" @default.
- W107198323 modified "2023-09-22" @default.
- W107198323 title "Clinical significance of GFR-Ccr difference value in differential diagnosis of patients with AFR and CRF." @default.
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