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- W107227914 abstract "OBJECTIVE: We compared the incidence of ICU admission among persons with MS and a matched cohort from the general population. BACKGROUND: Care in intensive care units (ICU) is costly, and consumes a disproportionate share of medical costs. Little is known about the risk of ICU admission in persons with multiple sclerosis (MS). DESIGN/METHODS: Using provincial administrative data we identified all persons with MS and an age, sex and geographically-matched general population cohort. For 2000-2010, we estimated the annual incidence and the 10-year cumulative incidence of ICU admission among prevalent cases of MS. Also, we estimated the incidence of ICU admission among a cohort with incident MS using Cox proportional hazards models adjusted for age at diagnosis, sex, comorbidity and socioeconomic status. RESULTS: From 2000-2010, the age and sex-standardized annual incidence of ICU admission ranged from 0.51% to 1.07% in persons with MS and 0.36-0.60% in the general population. The 10-year average annual incidence rates were 0.80% in the MS and 0.45% in the general populations. The crude 10-year cumulative incidence of ICU admission was 6.03% in MS and 3.45% in the matched cohort (incidence rate ratio [IRR] 1.53). When compared to the general population, the incidence of ICU admission was increased at all ages, but the relative risk was higher among persons aged 18-39 (IRR 3.67) than among persons aged 40-59 (IRR 1.97) and than among persons aged ≥60 years (IRR 1.38). When comparing incident cases of MS to the general population, the risk of ICU admission in a multivariable Cox model was increased (hazard ratio [HR] 1.45; 95% CI: 1.19-1.75). CONCLUSIONS: The risk of ICU admission is relatively high among persons with MS, particularly in younger MS patients. Given the recognized adverse consequences of critical illness in the general population, future studies should determine if there are modifiable risk factors for ICU admission. Supported by: The Manitoba Health Research Council and HSC Research Foundation. Disclosure: Dr. Marrie has received research support from Sanofi-aventis. Dr. Bernstein has received personal compensation for activities with Abbott, Janssen, Vertex Pharmaceuticals, Bristol-Myers Squibb Company, Mylan Pharmaceuticals, Ranbaxy Pharmaceuticals, and Barr Pharmaceuticals. Dr. Bernstein has received research support from Abbott and Aptalis Pharma. Dr. Peschken has nothing to disclose. Dr. Hitchon has received research support from UCB Pharma. Dr. Fransoo has nothing to disclose. Dr. Garland has nothing to disclose." @default.
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- W107227914 date "2013-02-12" @default.
- W107227914 modified "2023-09-27" @default.
- W107227914 title "Increased Risk of Intensive Care Unit Admission in Multiple Sclerosis (P03.205)" @default.
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